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Mini Review Volume 16 Issue 5
Thyroid dysfunction after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)
Noskova I, Spiliotis J, Spiliotis AE, Diamadis A, Apostolopoulos A
4th Department of Surgery and Surgical Oncology European Interbalkan Medical Center, Thessaloniki, Greece
Surgical Oncology Athens Medical Center, Athens, Greece
OncoSurgery IKE, Athens, Greece
Department of Surgery Medical School of Thessaly, Larisa, Greece
Department of Surgery Ygia Polyclinic, Limassol, Cyprus
Health Support IE, Athens, Greece
Received: November 29, 2025 | Published: December 18, 2025
Citation: Spiliotis J, Spiliotis AE, Diamadis A, et al. Thyroid dysfunction after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). J Cancer Prev Curr Res. 2025;16(5):140‒141 DOI: 10.15406/jcpcr.2025.16.00593
Abstract
Background: Cytoreductive
surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are complex
procedures associated with significant morbidity and mortality. Thyroid
dysfunction is increasingly recognized as a potential factor influencing
postoperative outcomes.
Objective:
This
study aimed to evaluate the effect of CRS and HIPEC on thyroid hormone and
cortisol levels, and their association with surgical outcomes.
Methods:
Four
hundred patients undergoing CRS and HIPEC for peritoneal metastases were
included. Patients with thyroid or endocrine disorders were excluded. Serum
levels of TSH, Free T3, Total T3, Free T4, Total T4, cortisol, and albumin were
measured preoperatively, intraoperatively, and on postoperative days 3, 6, and
10. Statistical significance was assessed using the paired Student’s t-test.
Results:
Free
T3 and Total T3 levels were significantly decreased on the first and sixth
postoperative days (p < 0.05). Cortisol levels increased significantly on
postoperative days 4, 6, and 10 (p < 0.05), with the highest levels observed
in patients with adverse events. TSH levels decreased initially but normalized
progressively. Albumin levels dropped significantly during the first week. Free
T4 and Total T4 showed no significant changes.
Conclusion:
Thyroid
dysfunction and cortisol response are common after CRS and HIPEC, with Free T3
levels correlating with shorter ICU and hospital stays, and TSH changes
associated with prolonged recovery. Preoperative and perioperative thyroid
assessment may optimize surgical outcomes.
Keywords: Chemotherapy,significant morbidity,mortality
©2025 Spiliotis, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.