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Case Report Volume 17 Issue 2
Heterogeneity of extensive invasive lobular carcinoma. part I: combination of the classic diffuse and solid forms
László Tabár, Peter B Dean, Miklós Tarján
Department of Mammography, Falun Central Hospital, Sweden
Department of Diagnostic Radiology, Faculty of Medicine, University of Turku, Finland
Department of Clinical Pathology and Cytology,Falun Central Hospital, Sweden
Received: April 23, 2026 | Published: May 6, 2026
Citation: Tabár L, Dean PB, Tarján M. Heterogeneity of extensive invasive lobular carcinoma. part I: combination of the classic diffuse and solid forms. J Cancer Prev Curr Res. 2026;17(2):56‒59. DOI: 10.15406/jcpcr.2026.17.00607
Abstract
Background: The imaging biomarkers of extensive breast malignancies termed invasive lobular carcinoma are non-calcified architectural distortion with or without associated spherical tumour masses. Microscopic examination of these extensive malignancies can reveal the following entities, either separately or in combination: the classic diffusely invasive form, the solid form, and the invasive form arising within multiple lobules. Case presentation: This report describes a combination of the classic diffusely invasive and solid forms, corresponding to the imaging biomarkers of architectural distortion and multiple circular/oval tumour masses, respectively, in a 90-year-old patient. She died from disseminated breast cancer. Histopathologic examination showed the diffuse form in the distant metastases. There were also challenging calcifications on the mammograms. Conclusions: The diffuse and solid forms of invasive lobular carcinoma occurred in combination in this case. The immunohistochemical biomarkers did not predict a fatal outcome. The diffuse form was the dominant malignancy in this case and is known to have the highest fatality rate of all breast cancers. Cell culture and imaging-histopathologic correlation provide evidence that the diffuse form has its origin in the mesenchymal stem cells and undergoes mesenchymal-epithelial transition, factors which can account for its consistently poor outcome over the past half century.
Keywords: Invasive lobular carcinoma, imaging biomarkers, breast cancer of mesenchymal origin, mesenchymal-epithelial transition
©2026 Tabár, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.