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Research Article Volume 9 Issue 2
Advances in Sarcopenia mouse models: establishment strategies and mechanisms
Yujiao Tang, Xinao Jia, Dongji Yang
Received: July 01, 2025 | Published: August 7, 2025
Citation: Tangs Y, Jia X, Yang D. Advances in Sarcopenia mouse models: establishment strategies and mechanisms. Int J Avian & Wildlife Biol. 2025;9(2):67-71. DOI: 10.15406/ijawb.2025.09.00235
Abstract
Sarcopenia is a common geriatric disease characterized by the decline of muscle strength, mass, and function. Its pathogenesis is complex and there is no unified conclusion. Establishing appropriate mouse models is fundamental to studying this disease. Currently, methods for constructing sarcopenia mouse models include induced injection, aging models, muscle atrophy models, and transgenic models. Each model has its applicable conditions and limitations. Therefore, through a literature review of sarcopenia, this paper summarizes the modeling methods and mechanisms of sarcopenia in mice and provides an overview, aiming to provide references for related research.
Keywords: sarcopenia, animal model, skeletal muscle aging, modeling method
©2025 Tangs, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.