Non invasive treatment for atrial fibrillation

doi:10.15406/oajtmr.2019.03.00060

Open Access Journal of

eISSN: 2576-4578

Translational Medicine & Research

Short Communication Volume 3 Issue 1

Non invasive treatment for atrial fibrillation

Federico Benetti,

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Natalia Scialacomo

Cardiac Surgery, Benetti Foundation, Argentina

Correspondence: Federico Benetti, Cardiac Surgery, Benetti Foundation, Alem 1846, Rosario, zip 2000, Argentina, Tel 005493415076262, Fax 00543414855827

Received: March 05, 2019 | Published: March 28, 2019

Citation: Benetti F, Scialacomo N. Non invasive treatment for atrial fibrillation. Open Access J Trans Med Res. 2019;3(1):8-9. DOI: 10.15406/oajtmr.2019.03.00060

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Abstract

Introduction: In 2005 we developed a non invasive method of treating the atrial fibrillation using radiation, based on the concept of producing cellular apoptosis.

Methods: Initially we enrolled trial fibrillation patients with prior catheter ablation for. In AF patients, CT was used to delineate atrial anatomy and targets. Planning software was used to design delivery of uniform, transmural ablative energy to the targets (cardioplan, Cyberheart Inc., Mountain View, CA); Radio ablation was performed with assistance from radiation oncologists and physicists (Cyberknife, Accuray, Inc., Sunnyvale, CA). Patients were monitored with interrogation, ambulatory monitoring, ECG, echo, chest X-ray, and clinical follow up. All patients were treated under approved IDE and IRB approvals. Four patients were treated at the moment

Results: The patients tolerate the procedure the average doses was 25Gy.

Conclusion: Ouers initially results in Humans after an extensive animal experimentation are promising More cases and follow up of the patients are needed to confirm these initially observations.

Keywords: radio surgery for arrhythmia, ablation non invasive of atrial fibrillation, radiation for non invasive treatment of atrial fibrillation

Introduction

Atrial fibrillation is the most frequent arrhythmia in clinical practice. Your diagnosis is electrocardiographic. It is defined as the replacement of P waves by rapid oscillations f waves; that vary in time of appearance form and size and are associated with an irregular ventricular response. It represents more than 10% of the hospitalizations. It carries a high morbidity and mortality and a very large increase in medical expenditure.^1–3 Cox et al.⁴ on the basis of multiple re-entrant circuits created the technique of Maze; is very efficient but difficult to reproduce and requires a great operation. This has led to develop other alternatives after knowing the role of pulmonary veins and posterior wall of left atrium as sources of origin and maintenance of atrial fibrillation. Several sources of power were originality used.^5,6 Radio frequency or not with cryoablation is currently the most frequent used by either catheterization or surgery;⁷ but also involves an invasive treatment.

In 2005 we developed a non invasive method of treating the atrial fibrillation using radiation, based on the concept of producing cellular apoptosis,⁸ Cyberheart system was create for this purpose.^9,10 Basically the system is a software that use an specific planning with 4D imaging of anatomic targets and tracking and compensate for movements the heart and patient with minimally radiation exposure to perform ablation of atrial fibrillation using a variety of radio surgery platforms.

Methods

Initially we enrolled, atrial Fibrillation patients with prior catheter ablation for. . In AF patients, CT was used to delineate atrial anatomy and targets. Planning software was used to design delivery of uniform, transmural ablative energy to the targets (cardioplan, Cyberheart Inc., Mountain View, CA); Radio ablation was performed with assistance from radiation oncologists and physicists (Cyberknife, Accuray, Inc., Sunnyvale, CA). Patients were monitored with interrogation, ambulatory monitoring, ECG, echo, chest X-ray, and clinical follow up. All patients were treated under approved IDE and IRB approvals. Four patients were treated at the momen.t

Results

The patients tolerate the procedure the average dosis was 25Gy.

Conclusion

Atrial fibrillation is the most common arrhythmia and is associated with poor prognosis ; because of the aging of the population the number of patients will increase by 2,5 times by the year 2050 Apart from the medical treatment. Radiofrequency catheter ablation and surgical technique are the most common invasive treatment today. Strategies to deal with the huge worldwide burden of atrial fibrillation will include a wider application of non-pharmacological therapies as well as a big investment in basic and clinical research. New and more effective antiarrhythmic drugs also are needed. For sure genetic studies will help in understanding the therapy of atrial fibrillation CyberHeart is the first non invasive system designed to ablate the atrial fibrillation using radiation. Ouers initially results in Humans after an extensive animal experimentation are promising more cases and follow up of the patients are needed to confirm these initially observations.