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Editorial Volume 2 Issue 4
A Need for Genetic Profiles of Alzheimer’s Disease Patients
Abdelaziz Ghanemi,1,2,3
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1Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming, Yunnan 650233, PR China
2Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China
3University of Chinese Academy of Sciences, Beijing, China
Correspondence: Abdelaziz Ghanemi, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology Chinese Academy of Sciences, No. 32 Jiao chang dong lu, Kunming 650223, China
Received: July 19, 2015 | Published: July 20, 2015
Citation: Ghanemi A (2015) A Need for Genetic Profiles of Alzheimer’s Disease Patients. J Neurol Stroke 2(4): 00062. DOI: 10.15406/jnsk.2015.02.00063
Editorial
Alzheimer’s disease (AD) is among the most known neurodegenerative disease1 and represents the most prevalent dementia.2 AD has been studied from different angles including biochemistry, proteomics, behavior, environmental factors and genetic risks.3 However, genetic factors seem to be limited due to the low percentage of AD cases in which genetics has been involved.
However, establishing a genetic profile of AD patients followed with statistical analysis of the obtained results might provide data allowing us to link specific genes or group of genes to AD. Such approaches could lie on the current understanding of the genetic aspects of AD as a starting point. Such project could be a part of the brain projects within a context of international collaborations toward a genetic explanation of AD that will allow us to elucidate some of the unknown underlying pathways, use the identified genes to build animals models of AD4 and eventually test some therapeutic candidates on the built animal models.
Importantly, those genes identify as related to AD risk or the pathways related or controlled by those genes could represent therapeutic targets toward developing new AD treatments if those genetic data are combined with the pharmacology5 (including the traditional medicines6 and pharmacognosy7), toxicology8, chemistry,9 zoology10 and cell culture methods.11,12
Acknowledgments
Abdelaziz Ghanemi is a recipient of a 2013 CAS-TWAS President's Postgraduate Fellowship.
Conflicts of interest
None.
References
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- Ghanemi A. Is mapping borders between pharmacology and toxicology a necessity? Saudi Pharm J. 2014;22(6):489–490.
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- Ghanemi A. How to define a pharmacological or a toxic food? Alexandria Journal of Medicine. 2014;doi:10.1016/j.ajme.2014.06.004.
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- Ghanemi A. How to map the bridges between zoology and pharmacology? The Journal of Basic & Applied Zoology. 2015;doi:10.1016/j.jobaz.2014.12.003.
- Ghanemi A. Cell cultures in drug development: Applications, challenges and limitations. Saudi Pharm J. 2014;doi:10.1016/j.jsps.2014.04.002.
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