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Letter to Editor Volume 2 Issue 6
A Prospective View of Therapeutic Strategy of Atherosclerosis in Cardiovascular Diseases
Xin Wang,1
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Yongjun Wang2
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1ACURE Biotechnology, INC., USA
2Department of Neurology, China
Correspondence: Xin Wang, ACURE Biotechnology, INC., Ellicott City, Maryland, USA
Received: May 26, 2015 | Published: May 30, 2015
Citation: Wang X, Wang Y (2015) A Prospective View of Therapeutic Strategy of Atherosclerosis in Cardiovascular Diseases. J Cardiol Curr Res 2(6): 00082. DOI: 10.15406/jccr.2015.02.00082
Keywords
Atherosclerosis; Mitochondria dysfunction; Lipids metabolism; Cardiovascular diseases; Clinical research; Drug discovery; Immunotherapy; Epigenetic gene markers; Collaboration
Letter to Editor
Atherosclerosis is chronic autoimmune inflammation; combining with accumulation of abnormal lipid metabolites taking place in tissue of vessels wall. In the past two decades; Dr. Wang Yongjun’scerebrovascular diseases research team has been studying for reducing morbidity and mortality of cardiovascular diseases caused by atherosclerosis through clinical research on stroke. This team studied the correlation between atherosclerosis and acute outbreak of stroke at the first time in China with imagine technology (CT and TCD) as early as in 1995 [1]. Then the team accessed and compared the four stroke evaluation scales that generally used in Europe; USA; Japan and China with acute stroke inpatients; which was the first time to bring the bridge of clinical research about stroke between China and the rest of world [2]. Knowing the significant of rehabilitation in outcome of stroke; Beijing Tiantan Hospital built stroke units setting for inpatients to satisfy the world standard of clinical research of stroke; and performed the therapeutic effects and prospective study of intervention and antiplatelet agents (Clopidogrel combining with Aspilin) application to atherosclerosis and stroke patients [3]; which provided the fundamental data for the guideline of primary and secondary prevention of cerebrovascular diseases in China. According to their achievement; an innovative system; Chinese Ischemic Stroke Subclassification (CISS) was created and spreadingly employed within hundreds hospitals offering standard and accurate classification for clinical information of stroke in China [4]. ACURE Biotechnology; INC.; backed with extensive basic and translational research in neuroscience; lipids metabolism; cell microenvironment; angiogenesis and infectious diseases; holds 5 patents in therapeutic and preventive strategies for vascular diseases. A novel gene with same N-terminal motif to G-couple proteins was originally discovered by this company’s founder as early as in 2001; had been demonstrated that is play important role in immune and brain associating with lipid rafts [5]. The founder later discovered that the intracellular accumulation of ceramide; the original backbone for most lipids; causes mitochondria dysfunction and leads to severe defect of development of cardiovascular in a Ceramide Transfer Protein (CERT) mutant mouse model [6]. Recently the company established an animal model studying the association between secretion of cytokines (IL17; VEGF) in infectious diseases and vascularization [7]. Thereby a hypothesize that mitochondria dysfunction of smooth muscle cells in vessels wall caused by hypertension; diabetes; high fat or glucose diets; viruses and bacteria infection; and diseases lowering blood oxygen; aging and degeneration diseases; produces abnormal lipids metabolites; which cause the local acute; then process to chronic inflammation; cell death and calcification--the pathological changes of atherosclerosis. Here address to this hypothesis; we summarize a comprehensive therapeutic strategy in atherosclerosis for our collaboration: Evaluating; monitoring and controlling the risk factors of stroke in a community system; Establishment of epigenetic gene markers to predict high-risk population of stroke for preventive medicine; Developing and discovering innovative immunotherapy and drugs to remove or stabilize atherosclerosis lesions; discovering new drugs to improve the formation of collateral circulation in brain after stroke; Combination of acute care; rehabilitation and traditional Chinese medicine to improve the outcome of stroke patients.
References
- Ding JP, Hua Y, Wang YJ, Ling C, Duan C, et al. (2001) The Distribution of Cerebral Atherosclerosis in the Patients with Acute Ischemic Stroke. China JMIT 17(1): 29-31.
- Wang X, Wang YJ (1999) A Comparative Study of Four Stroke Scales in Efficacy and Reliability. Chinese J of Physical Medicine and Rehabilitation 3: 140-143.
- Wang Y, Wang Y, Zhao X, Liu L, Wang D, et al. (2013) Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 369(1): 11-19.
- Gao S, Wang YJ, Xu AD, Li YS, Wang DZ (2011) Chinese Ischemic Stroke Subclassification. Front Neurol 2: 6.
- Wang X, Tian QB, Okano A, Sakagami H, Moon IS, et al. (2005) BAALC 1-6-8 protein is targeted to postsynaptic lipid rafts by its N-terminal myristoylation and palmitoylation, and interacts with a, but not b, subunit of Ca2+/calmodulin-dependent protein kinase II. J Neurochem 92(3): 647-659.
- Wang X, Rao RP, Kosakowska-Cholody T, Masood MA, Southon E, et al. (2009) Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J Cell Biol 184(1): 143-158.
- Zhang ZY, Ge XJ, Zheng WX, Chen RZ, Wang X (2014) VEGFA And IL17 Expression Reveals Their Potential Functional Crosstalk in Periodontitis Rats-A New Animal Model for Angiogenesis Study. J Microbiol Exp 1(4): 3-7.
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