International Journal of
eISSN: 2381-1803
Submit manuscript...
Short Communication Volume 6 Issue 1
Complimentary Effect of L Citrulline Supplementation on Shock Wave Therapy (SWT) Induced Angiogenesis
Zaman Mirza
Verify Captcha
Regret for the inconvenience: we are taking measures to prevent fraudulent form submissions by extractors and page crawlers. Please type the correct Captcha word to see email ID.
Verify Captcha
Regret for the inconvenience: we are taking measures to prevent fraudulent form submissions by extractors and page crawlers. Please type the correct Captcha word to see email ID.
Kharkiv National Medical University, Ukraine
Correspondence: Zaman Mirza, Kharkiv National Medical University, Prospect lenina 4, Kharkiv, Ukraine, Tel +380934706072
Received: December 06, 2016 | Published: March 23, 2017
Citation: Mirza Z (2017) Complimentary Effect of L Citrulline Supplementation on Shock Wave Therapy (SWT) Induced Angiogenesis. Int J Complement Alt Med 6(1): 00179. DOI: 10.15406/ijcam.2017.06.00179
Short communication
SWT is a modern day non invasive treatment option for a wide range of condition which includes ischemic heart disease, vasculogenic erectile dysfunction, soft tissue wound, traumatized bones, kidney stones etc. It works on the basis of Angiogenesis which promotes tissue healing by the means of vascularization of the affected tissue that eventually results into tissue regeneration thus rapid healing takes place. It induces improved hemodynamic in the affected tissue which is vital for healing process.
L citrulline is a non protein amino acid that converts into another amino acid named l arginine which is the precursor of nitric oxide. Nitric oxide is essential for vasodilation as it relaxes the blood vessels, thus it improves hemodynamics which plays an important role in the process of Angiogenesis.
L citrulline supplementation is more effective than l arginine supplementation, because it promotes more bioavailability of L arginine than l arginine supplementation itself due to its less pre-systemic and systemic absorption rate in the stomach and in the liver.
The concept is all about utilizing L citrulline supplementation to increase the efficacy of SWT.
Material and methods
SWT causes micro tears in the local small blood vessels and as a response the body releases angiogenic growth factors such as eNOS, VEGF, PCNA etc. Thus induces the process of Angiogenesis. The enzymatic action of eNOS converts L arginine into nitric oxide to induce vasodilation which promotes angiogenesis and as the process of Angiogenesis progresses, the required amount of Nitric oxide thus l arginine increases as well.
Results and discussion
L citrulline supplementation ensures a constant bioavailability of L arginine which meets the increase requirement thus assisting the process of Angiogenesis induced by SWT to be continued without any disruption.
Conclusion
L citrulline supplementation can be utilized to support, accelerate and continue the process of SWT induced angiogenesis.
Funding
None.
Acknowledgments
None.
Conflicts of interest
The author declares that there are no conflicts of interest.
©2017 Mirza. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.