Diagnostic dilemma of hyaline cystic degeneration of uterine fibroids

doi:10.15406/ogij.2019.10.00444

eISSN: 2377-4304

Obstetrics & Gynecology International Journal

Case Report Volume 10 Issue 3

Diagnostic dilemma of hyaline cystic degeneration of uterine fibroids

Matthew Anyanwu,^1,2

Verify Captcha

Regret for the inconvenience: we are taking measures to prevent fraudulent form submissions by extractors and page crawlers. Please type the correct Captcha word to see email ID.

Gassama K,¹ Kandeh M¹

¹Edward Francis Small Teaching Hospital Banjul the Gambia (EFSTH)
²University of the Gambia Medical School

Correspondence: Matthew Anyanwu, Senior Lecturer University of the Gambia School of Medicine and Allied Sciences department of Obstetrics and Gynaecology, University of the Gambia Medical School, P.O.Box1646 UTG Banjul, Gambia, Tel (220)-9922933 or (220)-7786700

Received: April 28, 2019 | Published: May 28, 2019

Citation: Anyanwu M, Gassama K, Kandeh M. Diagnostic dilemma of hyaline cystic degeneration of uterine fibroids. Obstet Gynecol Int J. 2019;10(3):202-205. DOI: 10.15406/ogij.2019.10.00444

Download PDF

Abstract

Various forms of degenerations may occur in fibroids but cystic and myxoid degenerations are not common. We reported two case series of cystic degenerations in pregnant and non-pregnant conditions. A myomectomy on pregnant uterus and total abdominal hysterectomy and bilateral salpingoophorectomy was respectively performed successfully. There was diagnostic dilemma in both cases prior to surgical intervention as available imaging investigations made diagnosis of ovarian cystic mass. Magnetic resonant imaging was not available but evidence suggests preoperative use may resolve the diagnostic dilemma.

Introduction

As fibroids enlarge, they outgrow their blood supply which may evoke cascade of inflammatory reactions and ischaemic changes leading to various types of degenerations. Hyaline (60%),; Cystic (4%),; Red (3%), Myxoid (1-3%); Calcified (4%); Sarcomatous degeneration (0.1-0.8%).¹ Hyaline cystic degenerations are rare as only case reports were found in the literature.¹ The distinctive description of our second case series was a combination of 3 possible degenerations (Hyaline, Cystic and Myxoid) which is extremely rare. The sonographic features were complex; together with the patient’s clinical features was indistinguishable from ovarian tumour. They mimic ovarian tumour causing diagnostic dilemma.

Case 1

A 30 year old multipara in her 4th pregnancy at 11 weeks gestation presented with acute abdominal pain and haemodynamic instability. Ultrasound revealed cystic mass, posterior to the gravid uterus of 11 weeks 2 days gestation. A laparotomy was done and a subserous cystic degenerated fibroid at the posterior wall measured 6×7cm was resected haemostasis secured.

Case 2

Mrs BJ a 38 Year old nulliparous lady presented with abdominal pain and swelling for 5 years and irregular painful menses for 3years. She had 2 previous surgeries, a myomectomy 2009 and laparotomy 2013 at the surgical department, nothing was removed. She was cachectic; mildly pale, anicteric and all vital signs were within normal range. Abdomen was distended, midline scar from Xyphysternum to pubic symphysis, measured 41cm×38cm; SFH? 41cm; fluid thrill was positive.

Investigations were performed and the results were as follows; HB: 9.9g/dl; Group: “O” Negative 3 pints of blood was crossed matched; FBC/RFT/LFT: were all normal; HCG: NEGATIVE, HIV=Negative; Alpha Feto protein=negative; LDH=340 [303---618]; HBsAg=Negative; Total BiL: 5.0umol/L; CA 125 Not Available; Chest X-Ray and ECG=normal. Ultrasound and CT -Scan suggested “Ovarian Malignancy”!! At laparotomy a huge cyst of 41cm×38cm originating from the anterior uterine wall with multiple adhesions, cystic fluid measured about 8.2litres. She had uneventful post-operative recovery and was discharged on day 5. The histopathology result confirmed hyaline cystic degeneration of uterine fibroids. The preoperative imaging mimicked ovarian tumour. A diagnostic dilemma!!

Figure 1 shows the sonographic image of the patient with cystic and solid areas and some characteristics similar to papillary projections (Figure 2) (Figure 3).

Figure 1 Published with patient's consent.

Figure 2 cystic mass not ovarian but uterine?.

Figure 3 Uterine cystic mass.

Figure 4 cystic mass not ovarian but uterine?.

Figure 4 published with consent and permission of the patient.

Discussion

A leiomyoma or fibroid is a benign tumour presenting as the most common uterine neoplasm with a prevalence of 20%-30% in the women of reproductive age and more than 40% of women above 40 years of age^.2

As fibroid is common in reproductive age group therefore pregnancy coexisting with fibroid is not uncommon with a prevalence rate estimated at 10.7% in the first trimester.³ Varieties of fibroid degenerations can also occur in pregnancy. Red degeneration of fibroid in pregnancy is a well-established debilitating condition in the second and third trimesters. The basis for antenatal myomectomy stems only from case reports and small case series of up to 18 women.⁴ Therefore, it may not be a routine practice but required appropriate justification such as for severe pain from a degenerating fibroid, a large or rapidly enlarging fibroid, fibroids greater than 5cm in diameter within the lower uterine segment, or torsion of a pedunculated fibroid.^5–9 The most suitable time to undertake a myomectomy is considered to be during the first and second trimesters.⁵ In our case series the management was by antenatal myomectomy due to severe pain which was from the cystic degeneration of a posterior subserous fibroid. The diagnosis was made at surgery. Preoperatively the ultrasound diagnosis was a complex ovarian cyst in pregnancy. As pregnancy was less than 13 weeks and conservative management was not able to improve clinical condition, myomectomy was performed and adequate haemostasis was achieved. Patient made good recovery and pregnancy was carried to term. Caesarean section was performed and a live birth was achieved.

Case 2

The unavailability of CA 125 also added to the dilemma of arriving at a diagnosis. Although in premenopausal women, elevated CA-125 may occur in benign conditions including fibroids. However, the rate of elevation may not be comparable with malignant epithelial tumours of the ovary. The CT-scan was not able to distinguish the origin of the tumour but was in agreement with the ultrasound findings of a cystic mass with features suggestive of ovarian malignancy. We do not have MRI at the time and could not have done it. However, if MRI was performed probably we could have arrived at a diagnosis before surgery. Similar to case 1 as MRI is safe in pregnancy¹⁰ we could have made the diagnosis prior to surgery. The study by Kaushik, et al.¹ managed two cases of cystic degeneration of fibroids. They had diagnostic dilemma and the diagnosis was confirmed at surgery. Tumour resection and hysterectomy was performed. The management was not different from ours as there was no preoperative diagnosis with primary intention to perform primary ovarian malignancy surgery total abdominal hysterectomy and bilateral salpingoophorectomy (TAH-BSO).

In 2004 and 2005 Low SCA et al.²; Maria Luisa et al.¹¹ respectively published a case of cystic leiomyoma mimicking an ovarian malignancy. The clinical features and investigations mimicked ovarian tumour. The diagnosis was at surgery. They managed by TAH BSO which was similar to how we managed our patient.

However, some radiologists working elsewhere had job satisfaction when their case series of radiological suspected cystic degenerations of the uterine fibroid were confirmed post -surgery when histology report was retrieved Hricak et al.¹²

In 2007; Maizlin et al.¹³ published a paper with this title: “Is It a fibroid? Are you sure?: the sonographic features supported ovarian tumour but their worries was resolved by MRI which assisted in the preoperative diagnosis of cystic degenerations of fibroids. The intra-operative findings were in agreement with MRI diagnosis. The availability and application of MRI made the difference in the management of their patient.

The place of MRI in the pre-operative diagnosis cannot be overemphasized.^14–16 The images below from MRI using T1 T2 weighted views delineate the origin of cystic mass better than other imaging techniques and should be well applied were appropriate in the preoperative management of patient’s with massive cystic swelling of the abdomen. The cost implication and inaccessibility of this tool limits the use in routine gynaecological practice (Figure 5) (Figure 6).

Figure 5 T2W published with permission.

T2 W

Figure 6 T1W published with permission.

Sagittal T1W

Challenges in the management

There was insufficient documentation during her initial clinical visit in case 2. No full documentation about the surgery done in 2013 (open & close surgery?).

Her clinical features and investigations from different places suggest ovarian cancer. CA125 was requested but not available.

Intra operative findings in these case series were different from what we thought and the Surgery was sensitive and difficult in case 1 and 2 respectively. Case 2 was difficult because of the previous surgeries causing massive adhesions and ovaries buried in the uterus which was unavoidably removed in the young age (38 years). Histopathology results confirmed uterine fibroids. A diagnostic dilemma!!!!!

Conclusion

Hyaline cystic degenerations of the uterine fibroids may be rare but not uncommon. It can occur in pregnancy and non-pregnant state in the reproductive age. Myomectomy in pregnancy is as yet reported in case series. In non –pregnant it may appear so massive with features suggestive of ovarian malignancy. However, with MRI, preoperative diagnosis may be achieved. The distinctive description of our second case series was a combination of three possible degenerations (Hyaline, cystic and Myxoid) which is extremely rare.