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Review Article Volume 8 Issue 1
From framework to fusion: engineering bone grafts for the spine’s future
Zhang, Yuqi, Tawil Bill
Received: July 01, 2025 | Published: July 29, 2025
Citation: Yuqi Z, Bill T. From framework to fusion: engineering bone grafts for the spine’s future. Open Access J Sci. 2025;8(1):136-142. DOI: 10.15406/oajs.2025.08.00256
Abstract
Tissue-engineered bone grafts represent a transformative advancement in orthopedic and spinal repair, offering biologically active alternatives to traditional autografts and allografts. This paper explores the global market landscape, clinical applications, and ongoing research in this rapidly evolving field. Key market drivers include an aging population, rising surgical volumes, and technological innovations in biomaterials and regenerative medicine. Clinically available products such as INFUSE®, Trinity ELITE®, Vitoss®, and FiberGraft® demonstrate current capabilities, while emerging solutions in clinical trials aim to enhance osteogenesis, integration, and mechanical performance. Together, these developments signal a paradigm shift toward personalized, multifunctional grafts that promise to improve patient outcomes in complex musculoskeletal conditions.
Keywords: tissue engineering, bone grafts, orthopedic repair, spinal fusion, biomaterials, biocompatibility, scaffold design, osteo-conductivity, regenerative medicine, degenerative bone disease, load-bearing defects, hydroxyapatite, polycaprolactone, clinical translation, bone regeneration
©2025 Yuqi, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.