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Research Article Volume 3 Issue 2
A review on β-lactam antibiotic drug resistance
Usman Umar Zango, Munir Ibrahim, Sadiq Abdurrahman Abubakar Shawai, Ibrahim Muhammad Shamsuddin
Received: December 31, 2018 | Published: April 5, 2019
Citation: Zango UU, Ibrahim M, Shawai SAA, et al. A review on ?-lactam antibiotic drug resistance. MOJ Drug Des Develop Ther. 2019;3(2):52-58. DOI: 10.15406/mojddt.2019.03.00080
Abstract
β-lactam antibiotics constitutes a broad class of antibiotic agents that contain β-lactam ring in their molecular structure these agents includes cephalosporins, monobactams, penicillins and carbapenems. These are the most widely used antibiotics which act by inhibiting the synthesis of the bacterial cell wall such activity leads to the lysis and death of the bacteria. Due to the wide applications of these antibiotics bacteria have developed resistance mechanism against these antibiotics which is usually mediated by the enzymes β-lactamases, it hydrolyses β-lactam ring of the β-lactam antibiotics rendering it inactive. Recent studies have revealed that the combination of β-lactam antibiotics with β-lactamase inhibitors can be used to successfully overcome the effect of β-lactamases. This review discussed the mechanism of β-lactam antibiotic activity, the mechanisms of β-lactam antibiotic resistance and how to overcome the effect of the β-lactamases.
Keywords: beta-lactamases; beta-lactam; penicillin-binding protein; Penicillin, amp-genes
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