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Short Communication Volume 3 Issue 1
An efficient metal-ligand catalyzed Heck-type reaction for β,β-double arylation of acrylates
Franz-Josef Meyer-Almes, Benjamin Wolff
Department of Chemical Engineering and Biotechnology, University of Applied Sciences, Germany
Received: February 20, 2019 | Published: February 28, 2019
Citation: Wolff B, Meyer-Almes FJ. An efficient metal-ligand catalyzed Heck-type reaction for ?,?-double arylation of acrylates. MOJ Biorg Org Chem. 2019;3(1):27-29. DOI: 10.15406/mojboc.2019.03.00094
Abstract
The Heck-Mizoroki reaction was further developed into a straightforward and efficient procedure that uses a basic metal-ligand system to synthesize β,β-diarylated acrylates and gives access to a pharmaceutical interesting class of products that is usually obtained under considerably harsher conditions and worse yields.
Keywords: alkenes, catalysis, one-pot synthesis, microwave reactions, Heck-Mizoroki reaction, tri(o-tolyl)phosphine, Pd-catalyzed reactions, Heck-Mizoroki reaction, acrylic esters, ?,?-diarylated acrylates, methyl acrylate,
©2019 Wolff, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.