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Research Article Volume 5 Issue 6
Iron and its related parameters in serum and saliva of Iraqi patients with non-alcoholic and alcoholic liver disease
Hathama Razooki Hasan, Hiba Qasim Mahmoud
Received: January 01, 1971 | Published: November 26, 2018
Citation: asan HR, Mahmoud HQ. Iron and its related parameters in serum and saliva of Iraqi patients with non-alcoholic and alcoholic liver disease. MOJ Addict Med Ther. 2018;5(6):249-253. DOI: 10.15406/mojamt.2018.05.00133
Abstract
Background: The liver is the major site for production of proteins that maintain systemic iron balance; it is a storage site for excess iron. The aim of this project is to look for the differences in iron status in patients with non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) compared to that of control and to assess whether saliva can be used as an alternative to serum to measure this status.
Methods: The present study included four groups of Iraqis male, (18 patients with NAFLD), (18 patients with ALD), (30 non-smokers and non-alcoholic control), and (20 smokers non-alcoholic control). The used samples of the study were saliva and serum and the measured parameters included [iron], total iron binding capacity (TIBC), and unsaturated iron binding capacity (UIBC), [transferrin], transferrin saturation, and [ferritin].
Results: The results in comparison with that of the control group's showed:-
- For NAFLD, there was a highly significant differences in salivary (UIBC, transferrin saturation), serum [ferritin], with a significant differences in salivary TIBC, [transferrin]. And no significant differences in serum ([iron], TIBC, UIBC, [transferrin], and transferrin saturation), and saliva ([iron], and [ferritin]).
- For ALD, there was a highly significant differences in serum [ferritin], with a significant differences in TIBC, UIBC, and [transferrin] in serum with a non-significant differences in salivary ([iron], TIBC, UIBC, [transferrin], and transferrin saturation), as well as serum ([iron], transferrin saturation, and [ferritin].
- The results of the correlation between the changes of the studied parameters in serum and saliva indicated that only for control 1 group (which consisted of non-smokers and non-alcoholic healthy individuals) a significant correlation was found in [iron].
Conclusion: An iron overload was found in serum of ALD patients with absence of this overload in NAFLD patients. Moreover, in saliva, the results of ALD patients indicated absence of iron overload. While in saliva of NAFLD patients, an iron overload was observed. Saliva cannot be used as an alternative diagnostic fluid sample in both ALD & NAFLD patients to measure the variations in the iron parameters included in the present study.
Keywords: non alcoholic fatty liver disease, alcoholic liver disease, iron overload, serum, saliva
©2018 asan, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.