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Research Article Volume 4 Issue 4
COVID-19 detection using SERS technique
Caroline Magdy, Fatma Issam, Pierre Amir, Sandra Adel, Sherif El Gohary
Received: July 30, 2020 | Published: August 17, 2020
Citation: Magdy C, Issam F, Amir P, et al. COVID-19 detection using SERS technique. MOJ App Bio Biomech. 2020;4(4):86?91. DOI: 10.15406/mojabb.2020.04.00141
Abstract
Using Surface-enhanced Raman spectroscopy (SERS) can be a more promising choice for obtaining a faster detection of COVID-19 than the PCR. PCR protocol amplifies the single segment of DNA to 100 billion copies after 40 doubling cycles to provide sufficient intensities of fluorescent signals for virus detection, which takes hours. In this paper, we proposed that the enhanced signals of SERS, which can identify single nucleotide polymorphisms and unique gene sequences, can provide a more economic and accurate detection that does not require the long time needed for DNA amplification of COVID-19. Our proposed diagnostic tool is based on technology of single molecule SERS which checks if the Raman shift of the sample signal matches with the recorded one of COVID-19. In addition, its portability property provides the allowance of its usage in places other than labs and healthcare facilities. Therefore, the superiority of using SERS over fluorescence is manifested in the acquirement of a few-minute detection of coronavirus by the action of a SERS laser rather than the long and expensive measures taken in PCR.
Keywords: SERS, COVID-19, single molecule, DNA, RNA, PCR, raman
©2020 Magdy, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.
