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Mini Review Volume 15 Issue 3
Chronic pain syndrome: a new look at etiopathogenesis and treatment
OD Rudkovska
Received: July 01, 2025 | Published: July 14, 2025
Citation: Rudkovska OD. Chronic pain syndrome: a new look at etiopathogenesis and treatment. J Neurol Stroke. 2025;15(3):62-64. DOI: 10.15406/jnsk.2025.15.00624
Abstract
Chronic pain (primary, idiopathic) is considered to be a multifactorial disease, the trigger of which is unknown. The hypothesis of chronic pain syndrome: in genetically predisposed individuals, prolonged negative factors (chronic stress) cause excessive pupil constriction via cortico-nuclear pathways, which is manifested by significant activation of the parasympathetic nervous system. Constricted pupils (reduced luminous flux) through the optic-vegetative system trigger pathological biochemical processes in the body, which leads to a deterioration in the physical and psychological conditions of patients. It is proposed to introduce into the protocol of treatment of chronic pain syndrome (and all somatic and mental diseases) the medical dilation of the pupils to relieve the negative effects of an overactive parasympathetic nervous system on the body.
Keywords: fibromyalgia, trigeminal neuralgia, pupil, opto-vegetative system, parasympathetic nervous system, mydriatic
©2025 Rudkovska. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.