Journal of
eISSN: 2373-6410
Submit manuscript...
Perspective Volume 15 Issue 6
Alzheimer’s disease: new perspectives- a review of emerging evidence-based concepts and therapeutics
Mark E McCaulley MD
Received: November 17, 2025 | Published: December 24, 2025
Citation: McCaulley ME. Alzheimer’s disease: new perspectives of emerging evidence-based concepts and therapeutics. J Neurol Stroke. 2025;15(6):178-180. DOI: 10.15406/jnsk.2025.15.00644
Abstract
In this review, I evaluate emerging evidence regarding the etiology and treatment of Alzheimer’s disease (AD), focusing on the limitations of the amyloid hypothesis and proposing a shift toward a framework centered on cholinergic failure. I argue that this failure results from an inflammation-induced cascade contributed to by infectious exposures (specifically HSV and VZV), potential toxic exposures exacerbated by genetic predisposition, and various lifestyle factors. Utilizing RNA-seq analysis of datasets from the Gene Expression Omnibus and ethically sourced liver tissue, I assess detoxification gene expression and its role in managing environmental stressors. I contend that the convergence of these factors culminates in a failure to maintain adequate levels of Nerve Growth Factor (NGF), resulting in the loss of viability of cholinergic nerves in the brain. Furthermore, I discuss risk assessment and stratification and provide options for risk management through targeted interventions. I prioritize cholinergic intervention and infectious control, followed by lifestyle and detoxification considerations, and discuss the potential of acetylcholinesterase inhibitors (AChEIs) in supporting neuronal survival.
Keywords: growth factor
©2025 McCaulley. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.