Journal of
eISSN: 2377-4282
Submit manuscript...
Research Article Volume 7 Issue 1
Architecting polymersomes from spherical to tubules by molecular alterations
Satarupa Dhir, Sumalee Salahub, Anu Stella Mathews, Carlo Montemagno, Sinoj Abraham
Received: January 01, 1971 | Published: February 26, 2018
Citation: Dhir S, Salahub S, Mathews AS, et al. Architecting polymersomes from spherical to tubules by molecular alterations. J Nanomed Res. 2018;7(1): 00176 DOI: 10.15406/jnmr.2018.07.00176
Abstract
Polymersomes formed by the self-assembling of block copolymers gained huge attraction recently due to it numerous potential applications especially as nano-reactors, tunable controlled delivery carriers, templates for bio-mineralization etc. The self-assembly of these block copolymers amphiphiles into monodisperse structures in aqueous solutions is influenced by their hydrophobic and hydrophilic molecular regions. However the commonly investigated structures are spherical vesicles, micelles and worm like micelles. This study focuses on generating tubular vesicles or “Tubularsomes” by altering the amphiphilic block length of the polymer chain. Polyoxazoline (POx) is covalently conjugated with polydimethyl siloxane (PDMS) to form block copolymers and explored the self-assembling behavior with special focus on the influence of chain length forming various structures. Additionally, the current limitations in the reproducibility and biocompatibility during the synthesis and utilization of biologically important polymer vesicles are explored along with enabling the development of these nanostructures towards real-world applications.
Keywords: Polylactic acid, Tubularsomes, Vesicles, Packing parameter, Encapsulate, Biological, Nano-medical systems, Traditional liposomes, Hydrophilic domains, Blood vessels, Dynamic light, Scattering, Temperature, Volume fractions, Nucleophilic, Polymersomes
©2018 Dhir, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.