Journal of
eISSN: 2377-4282
Submit manuscript...
Opinion Volume 7 Issue 2
Future of graphene in bio-medical application
Sandip Bhattacharya
School of VLSI Technology, Indian Institute of Engineering Science and Technology, India
Correspondence: Sandip Bhattacharya, School of VLSI Technology, Indian Institute of Engineering Science and Technology, Shibpur, India, Tel 07075654909
Received: April 10, 2018 | Published: April 24, 2018
Citation: Bhattacharya S. Future of graphene in bio-medical application. J Nanomed Res. 2018;7(2):186 ? 187. DOI: 10.15406/jnmr.2018.07.00185
Opinion
Over the last few decades, the graphene technology develops rapidly in different areas of application like nano-electronics,1 composite materials,2–6 sensors,7 energy technology8–10 etc. Graphene basically a 2D nano-materials extracted from 3D graphite, invented by Prof. Andre Geim and Prof. Konstantin Novoselov (Nobel Prize winner 2010, University of Manchester). Graphene is mechanically and thermally a stable material and it is 40 times harder than diamonds for that reason it is much more reliable and durable material.11 In this topic we are focused on future of graphene in bio-medical application. The recent study on artificial retina implants already developed by Glaxo Smith Kline to treat diseases using graphene based electrical stimuli.12 Graphene is also useful material for birth control and it prevents the sexually transmitted dieses reported by University of Manchester researcher’s team. The Graphene is one of the attractive material for cancer treatments. Recently a new microfluidic bio-chip based on graphene oxide being developed which can caught the tumor cells from blood and support their growth for further analysis.13 The graphene oxide (GO) is one of the efficient nano-carrier for drug delivery reported by Dai et al.14 The Genetic therapy using Graphene oxide (GO) is one of the promising approach to treat various diseases caused by genetic disorders, Parkinson's disease, cystic fibrosis etc.15 Graphene is also useful for bio sensing and bio-imaging. Basically doped graphene, pristine graphene, graphene oxide (GO) and chemically reduced GO (rGO) are useful for bio-sensing application. Using these material we can detect different kind of biomolecules such as thrombin, dopamine, oligonucleotide, ATP, amino acid etc.16–20 Here, I have explained few recent review work on graphene based nano-material and its application in medical domain. Hopefully, in near future I can contribute some work on graphene for medical application.
Conclusion
Compared with other fields, we have seen that graphene is progressing dramatically in the field on biomedical applications and is expanding rapidly. The technological advancement made in this research area is remarkable, exciting and encouraging. Still we are facing lots of challenges, however, in near future we must overcome such kind of challenges.
Acknowledgements
None.
Conflict of interest
The authors declare no conflict of interest.
References
- Xuan Y, Wu YQ, Shen T, et al. Atomic-layer-deposited nanostructures for graphene-based nanoelectronics. Appl Phys Lett. 2008;92(1):013101–013103.
- Yang XM, Tu YF, Li L, et al. Well-dispersed chitosan/graphene oxide nanocomposites. ACS Appl Mater Interfaces. 2010;2(6):1707–1713.
- Fan HL, Wang LL, Zhao KK, et al. Fabrication, mechanical properties, and biocompatibility of graphene-reinforced chitosan composites. Biomacromolecules. 2010;11(9):2345–2351.
- Bai H, Li C, Wang XL. A pH-sensitive graphene oxide composite hydrogel. Chem Commun. 2010;46(14):2376–2378.
- Sun ST, Wu PY. A one-step strategy for thermal- and pH-responsive graphene oxide interpenetrating polymer hydrogel networks. J Mater Chem. 2011;21(12):4095–4097.
- Fang F, Long J, Zhao WF, et al. pH-Responsive chitosan-mediated graphene dispersions. Langmuir. 2010;26(22):16771–16774.
- Lu CH, Yang HH, Zhu CL, et al. A graphene platform for sensing biomolecules. Angew Chem Int Ed Enql. 2009;121(26):4879–4881.
- Liu C, Alwarappan S, Chen ZF, et al. Membraneless enzymatic biofuel cells based on graphene nanosheets. Biosens Bioelectron. 2010;25:1829–1833.
- Stoller MD, Park S, Zhu YW, et al. Graphene-based ultracapacitors. Nano Lett. 2008;8(10):3498–3502.
- Wang L, Lee K, Sun YY, et al. Graphene oxide as an ideal substrate for hydrogen storage. ACS Nano. 2009;3(10):2995–3000.
- Novoselov KS, Geim AK, Morozov SV, et al. Electric field effect in atomically thin carbon films. Science. 2004;306(5696):666–669.
- Famm K, Litt B, Tracey KJ, et al. Drug discovery: A jump-start for electroceuticals. Nature. 2013;496:159–161.
- ReáteguiE, van der Vos KE, Lai CP, et al. Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Nat Com. 2018;9(1):175.
- Liu Z, Robinson JT, Sun XM, et al. PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc. 2008;130(33):10876–10877.
- Yang ZR, Wang HF, Zhao J, et al. Recent developments in the use of adenoviruses and immunotoxins in cancer gene therapy. Cancer Gene Ther. 2007;14:599–615.
- Chang H, Tang LH, Wang Y, et al. Graphene fluorescence resonance energy transfer aptasensor for the thrombin detection. Anal Chem. 2010;82(6):2341–2346.
- Wang Y, Li ZH, Hu DH, et al. Aptamer/graphene oxide nanocomplex for in situ molecular probing in living cells. J Am Chem Soc. 2010;132(27):9274–9276.
- Tang LH, Wang Y, Liu Y, et al. DNA-directed self-assembly of graphene oxide with applications to ultrasensitive oligonucleotide assay. ACS Nano. 2011;5(5):3817–3822.
- Dong XL, Cheng JS, Li JH, et al. Graphene as a novel matrix for the analysis of small molecules by MALDI-TOF MS. Anal Chem. 2010;82(14):6208–6214.
- Wang Y, Li YM, Tang LH, et al. Application of graphene modified electrode for selective detection of dopamine. Electrochem Commun. 2009;11(4):889–892.
©2018 Bhattacharya. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.