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Review Article Volume 6 Issue 2
The most important herpesviral infections in animals and humans
Iman M Bastawecy
Department of Virology, Animal Health Research Institute, Egypt
Received: April 06, 2018 | Published: August 2, 2018
Citation: Bastawecy IM. The most important herpesviral infections in animals and humans. J Hum Virol Retrovirol. 2018;6(4):66-67. DOI: 10.15406/jhvrv.2018.06.00197
Abstract
The most unique feature of herpesvirus is associated with the latency stage in the affected host and the subsequent reactivation of recurrent infection. Their oncogenic potential and viral integration into the host chromosomes also makes them unique among viruses. Malignant catarrhal fever (MCF) caused by ovine herpesvirus 2 (OvHV-2) was diagnosed in Egypt, 2012 by electron microscopy (EM) which detected herpes viral particles and it also excluded other viral diseases having the same symptoms. OvHV-2 is similar to Epstein-Barr virus (EBV) for encoding the homologous two cellular Bcl-2 proteins. ORF43 and ORF63 genes were found to be a homolog for herpes simplex virus (HSV) UL6 and UL37. EB viral particles were first noted by EM in a malignant burkit’s lymphoma in 1964. Surveillance for possibility of humans to be infected with OvHV-2 is recommended due to alot of conditions in addition to cases of pancreatitis especially for children who may result in pancreatic failure and diabetes myelitis as well in addition to testing of patients with autoimmune disorders, melasma and skin depigmentation for infection with OvHV-2. Also, sequencing of complete genome such as gB for OvHV-2, HSV and EBV must be performed and compared with reference OvHV-2, HSV and EBV to exclude misdiagnosis between them. Moreover, testing of poultry, aquatic species and pet animals for infection with OvHV-2 is recommended
Keywords: Poultry, Viruses, Skin, Eczema, Autoimmune, Disorders, Melasma, Skin depigmentation, Infection, OvHV-2m, Genomic, Nasopharyngeal, Gamma, Herpes, Nucleotide, Homologous
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