Case Report Volume 9 Issue 1
1Department of Molecular Medicine, University of Padua, Italy
2DDS, School of Dentistry, Isfahan (Khorasgan) Branch Islamic Azad University, Iran
3Department of Laboratory Sciences, Shahrekord University of Medical Sciences, Iran
4Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Iran
5Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Italy
Correspondence: Poorya Davoodi, MS, Department of Molecular Medicine, University of Padua, Padua, Italy
Received: June 28, 2022 | Published: July 4, 2022
Citation: Hashemi A, Davoodi P, Dehnavi NY, et al. Interaction of dermal filler and COVID-19’s mRNA vaccine. J Hum Virol Retroviral. 2022;9(1):31-33. DOI: 10.15406/jhvrv.2022.09.00243
Coronavirus 2019 has changed the life of the people and leads to death of more than 5.9 million people worldwide. In December 2020, two vaccines against COVID-19 were approved by Food and Drug Administration that are mRNA vaccines. While there are some concepts to produce special proteins against viral infections like mRNA, but for the first-time technology of using mRNA as a vaccine for producing certain proteins to cure patients. Some studies reported that there are some interactions between mRNA vaccines and dermal fillers and the main question is that mRNA vaccines are safe or not.
Keywords: mRNA, COVID-19, filler, mRNA vaccines, Inflammation, coronavirus
FDA, Food and Drug Administration; HIV, Human immunodeficiency virus; AIDS, Acquired immunodeficiency syndrome; mRNA, Messenger RNA; DHR, Delayed hypersensitivity reaction; HA, Hyaluronic acid; SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2
The COVID-19 is the most terrible challenge worldwide and it is caused by Sars-CoV-2.1 In December 2019, the first case observed in Wuhan (China) and by fast-growing mutations, new variants of original coronavirus have emerged. The coronavirus 2019 had has devastating effects and caused to more than 5.9 million deaths.2 A significant aspect to highlight during this crisis is the speed of studies that have been developed to a better understanding of clinical manifestations, risk factors, transmission factors, and ways to deal with the diseases, as well as to the identification of the etiological agent, structure of the virus, its genome, its intracellular replication, and the immune response of the infected individuals.3 All the studies have been done aim at finding the best strategy for diagnostic tests, clinical management, effective antiviral agents, and producing the vaccine.4 During the pandemic, finding an effective vaccine against the COVID-19 was the main aim of the all the scientists around the world, hence different pharmaceutical companies tried to find the best strategy for the making a vaccine. For many years, scientists have worked to produce particular proteins against viral infections by using mRNA, but the technology of using mRNA as a vaccine for making certain proteins to cure patients who have a viral disease was not trustable until the current pandemic.5–7
There are three main type of COVID-19 vaccines in use around the world: mRNA vaccine (Pfizer BioNTech & Moderna) Adenovirus-based (AstraZeneca, Johnson & Johnson and Russian`s Sputnik) and Inactivated SARS-CO2 virus like Sinovac Biotech.5,8 Between them, the most important in terms of many scientists is mRNA vaccines, because this type of vaccines have changed the Vaccine industry it was a revolution in the medical science.4,6 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine is made based on mRNA molecule, has had high success, and is a good document for persons who have no trust in mRNA vaccines.5,9–11The two efficient COVID-19 vaccines (Pfizer BioNTech and Moderna) were confirmed by the U.S. Food and Drug Administration (FDA) in December 2020 that was a turning point in action against the pandemic situation.12,13 Pfizer vaccine with 95% efficiency against COVID-19 infection, prescribed on days 0 and 21 that have been effective for all age and racial groups. While the Moderna vaccine had 94% effectiveness against coronavirus, it was less efficient for aged 65 and over but the same in all racial groups and administrated on days 0 and 28. The effectiveness of vaccines was measured 7 days after and 14 days after the second dose, respectively in Pfizer and Moderna.14 Some side effects were observed in most of the persons who were vaccinated by the Moderna vaccine, for instance, the pain at the injection site, tiredness, and temporary facial Inflammation.15
The immunological reaction can be created in persons who possess dermal filler, during infection to viral diseases such as COVID-19. According to the FDA report, the interaction between dermal filler and immune response after and before vaccination can cause a swelling response in persons with dermal filler.16 Around the cutaneous adverse events accrued to the immunization by COVID-19 vaccines, mRNA vaccines indicated a rare reaction to dermal filler.17 In Table 1, you can see the information of the patients who had dermal filler and experienced immunological reaction due to vaccination with mRNA vaccines. Waves of new variants are currently being discovered; the omicron variant contains roughly 50 mutations that have never been seen together before. Extra protection against the virus will almost certainly necessitate new vaccine formulations, raising questions about whether booster doses may need to be given continuously, perhaps increasing the risk of delayed hypersensitivity reaction (DHR) in hyaluronic acid (HA) patients.18 Based on the assessment of the different reports, scientists believe that by using mRNA and its applications a new period for controlling infectious disease and preventing its outbreak start. Nowadays, different pharmaceutical companies are trying to make mRNA vaccines against different diseases such as HIV/AIDS.
Number |
Type of vaccine |
Filler injection |
Age & Sex |
Time of injection |
Symptoms |
|
1 |
COVID-19 POSITIVE |
HA filler not specified region |
50, F |
Aug-20 |
Lips, cheeks burning, and tear troughs. |
|
2 |
COVID-19 POSITIVE |
Various parts of the face |
32, F |
Six years ago |
Unexpected swelling |
|
3 |
COVID-19 POSITIVE |
non- surgical rhinoplasty with HA |
22, F |
Jul-20 |
Swelling, edema, induration, erythema, moderate, tenderness, around the radix |
|
4 |
First dose Pfizer-BioNTech |
Into the tear trough |
39, F |
Oct-20 |
Swelling, headache, myalgias, anorexia, and headache |
|
5 |
First dose Pfizer-BioNTech |
At the zygomatic arch, chin, jawline, and tear trough |
61, F |
Jun-20 |
Swelling |
|
6 |
Second dose Pfizer-BioNTech |
Aesthetic facial rejuvenation and contour enhancement of superficial wrinkles |
43, F |
2019 |
Swelling and tenderness |
|
7 |
First dose Pfizer-BioNTech |
The cheeks |
76, F |
2019 |
Periorbital edema and Inflammatory pan facial |
|
8 |
First dose Pfizer-BioNTech |
into her temples and cheeks |
43, F |
2019 |
Swelling in the periorbital area |
|
9 |
Second dose of the Moderna vaccine |
On the lips, earlobes, nasolabial folds, and cheeks |
31, F |
Fall 2018 |
Swelling and Inflammation |
|
10 |
The first dose of the Moderna vaccine |
Bilateral tear troughs, Upper and lower portion of the lips |
36, F |
Nov-19 |
Swelling, perioral edema, inflammation, Fewer, malaise, lethargy, myalgias, Developing bilateral infraorbital |
|
11 |
HA fillers |
51, F |
||||
12 |
First and second dose Pfizer-BioNTech |
Into the lips. |
32, F |
2020 |
Swelling, edema, painful erythematous, mild pain |
|
13 |
second dose of the Moderna vaccine |
To the chin |
26, F |
2018 |
Chin enlargement, difficulties in speech, headache, and paresthesia |
|
14 |
the second dose of the Sinopharm vaccine |
In both hands |
62, F |
2019 |
Swelling, Nodules with stone-loke firmness in the back of both hands, adding pain |
|
15 |
The first dose of AstraZeneca COVID-19 vaccine |
In the lips, chin, malar, nasojugal furrow |
35, F |
2016, 2020 |
Edema and induration in her chin and lips |
|
16 |
second dose Pfizer-BioNTech |
Around the eye |
47, F |
Feb-21 |
Swelling and Edema |
|
17 |
First dose Pfizer-BioNTech |
In the superior and inferior lips |
34, F |
Dec-20 |
Edema and Pain in the area of HA administration |
|
18 |
First dose Pfizer-BioNTech |
In the chin and mandibular (jaw angle) |
56, F |
Sep-20 |
Pain and induration in the area of HA administration |
|
19 |
second shot of AstraZeneca COVID-19 vaccine |
In the nasolabial folds and lips |
43, F |
May-20 |
Edema, erythema, fever, the sensation of fatigue, redness on her lips |
Table 1 Information of the patients who had dermal filler and experienced immunological reaction with mRNA vaccines
In conclusion, the immune response of the body could be stimulated by viral diseases such as COVID-19 and flu especially in persons with dermal filler in the face that have experienced Inflammation in the same place that filler has been injected. Besides, this reaction of the body was specified as a natural infection that can be eliminated by the administration of antihistamines or steroids and did not have signs of dangerous diseases.
None.
None.
©2022 Hashemi, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.