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Short Communication Volume 12 Issue 1
Epigenetic and feedback loop regulation of BMPGREM1-SHH pathways in kidney development and cancer progression
Alexandre Gonçalves
Received: December 20, 2024 | Published: January 30, 2025
Citation: Gonçalves A. Epigenetic and feedback loop regulation of BMP-GREM1-SHH pathways in kidney development and cancer progression. J Hum Virol Retrovirol. 2025;12(1):12-14. DOI: 10.15406/jhvrv.2025.12.00281
Abstract
The BMP-GREM1-SHH signaling pathways play pivotal roles in regulating cell differentiation, progenitor maintenance, and tissue development. Dysregulation of these pathways contributes to kidney malformations and cancer progression. Here, we use integrated simulations, ChIP-seq analyses, and computational models to uncover novel insights into the epigenetic regulation and feedback dynamics of BMP-GREM1-SHH pathways. Our findings reveal critical interactions in kidney morphogenesis, including SHH-BMP synergy in nephron formation and Gli3-mediated transcriptional regulation. Additionally, we identify therapeutic targets, such as GREM1 inhibitors and BMP7 mimetics, for mitigating pathway dysregulation in renal cell carcinoma (RCC). These results provide a foundation for novel therapeutic interventions and a deeper understanding of genetic regulation in development and disease.
Keywords: SHH pathway, BMP pathway, canger progression, epigenetic regulation
©2025 Gonçalves. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.