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Case Report Volume 8 Issue 4
Hungry bone-like syndrome in a patient with bone-metastatic prostate cancer following radiotherapy: a case report
Amir Medhioub, Georg Bollig,
Received: December 29, 2025 | Published: December 31, 2025
Citation: Medhioub A, Bollig G. Hungry bone-like syndrome in a patient with bone-metastatic prostate cancer following radiotherapy: a case report. Hos Pal Med Int Jnl. 2025;8(4):73-75. DOI: 10.15406/hpmij.2025.08.00277
Abstract
Hungry bone syndrome is a rare complication that usually occurs after parathyroidectomy. In the literature, only a few cases have been reported in prostate cancer patients almost all with osteoblastic bone metastases. We present the case of a 63-year-old patient with osteolytic bone metastases from prostate cancer, who developed a hungry bone syndrome after starting radiotherapy and concurrent hormone ablation with bicalutamide. The patient developed severe electrolyte disturbances, including hypocalcaemia, hypophosphatemia, hypokalaemia, and hypomagnesemia, along with elevated parathyroid hormone (PTH) levels. In this case, we assume that therapy in the presence of osteolytic bone metastases triggered the hungry bone syndrome, most likely through osteoblast activation leading to redistribution of minerals into bone tissue.
Keywords: radiotherapy, palliative treatment
©2025 Medhioub, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.
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