The use of Ammi visnaga in the treatment of prediabetes and weight loss: the antioxidant impacts in diabetes treatment as a new medical hypothesis

doi:10.15406/aowmc.2020.10.00323

Advances in

eISSN: 2378-3168

Obesity, Weight Management & Control

Mini Review Volume 10 Issue 6

The use of Ammi visnaga in the treatment of prediabetes and weight loss: the antioxidant impacts in diabetes treatment as a new medical hypothesis

Ahed J Alkhatib^1,2

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¹Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science & Technology, Jordan
²Department of medicine and critical care, department of philosophy, Academician secretary of department of Sociology, Jordan

Correspondence: Ahed J Alkhatib, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University Of Science & Technology, Jordan

Received: October 11, 2020 | Published: November 9, 2020

Citation: Alkhatib AJ. The use of Ammi visnaga in the treatment of prediabetes and weight loss: the antioxidant impacts in diabetes treatment as a new medical hypothesis. Adv Obes Weight Manag Control 2020;10(6):169-70. DOI: 10.15406/aowmc.2020.10.00323

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Abstract

Introduction: Prediabetes status is considered as an important feature in either controlling the development or progression of diabetes. It may pass unnoticed because the symptoms of diabetes are usually not well established.

Study objectives: The main objectives of the present study were to explore the efficacy of using Ammi visnagain treating pre-diabetic cases and weight losing.

Methods and subjects: A prospective study was conducted to investigate the impact of using Ammi visnaga treatment of pre-diabetes and weight control. The study included 5 patients with pre-diabetes (glucose level was 128±32mg/dl). The age of patients was 42±18.5years. The study included 3 males and 2 females. In general, patients were overweight according to body mass index level was 28±7.8kg/m². The patients used the aqueous extract of Ammi visnaga for two months (200 ml daily).

Results: At the end of the experiment, the glucose level was significantly reduced (p<0.05)to the level of 88±12.5mg/dl. There was also a significant reduction in the level of BMI from 28±7.8kg/m² to 22±6.4kg/m2(p<0.05).

Conclusion: The results of the present study showed that Ammi visnaga has the therapeutic potential to control the progression of complete episodes of diabetes by controlling the pre-diabetic status.

Keywords: pre-diabetes, glucose, BMI, overweight, Ammi visnaga

Abbreviations

ADA, American diabetes association; BMI, body mass index

Introduction

At the worldwide level, the predominance of type 2 diabetes has drastically expanded.^1–3 Examination has demonstrated a huge connection among diabetes and every one of heftiness and insulin obstruction just as adjustments in the capacity of β-cells in the pancreas.^4,5 The subsequent impacts incorporate declining paces of insulin digestion, for example, glucose, lipids, and proteins.⁶ Diabetes can bring about regulatory changes in the hemostasis of calcium, phosphorus and magnesium finishing with genuine confusions including cardiovascular sickness and neurological problems.^7,8 As indicated by the American Diabetes Association (ADA), pre-diabetes can be characterized as either impedance of fasting glucose (5.6–6.9 mmol/L) or alteration of oral glucose tolerance test (2-h OGTT glucose 7.8–11.0mmol/L).⁹ Different investigations indicated that the pre-diabetic state is described by a decrease of glucose tolerance and lowered insulin secretion.¹⁰ It has been exhibited that the condition of pre-diabetes is related with creating cardiovascular occasions, for example, myocardial anomalies. Appropriately, as ahead of schedule as the cardiovascular changes have been resolved in this express, the outcomes are ideal in forestalling the advancement of heart illnesses.¹¹

Study objectives

The main objectives of the present study were to explore the therapeutic potential of Ammi visnagain treating pre-diabetic cases and lowering weight.

Material and methods

Study design: A prospective study was conducted to examine the impact of using Ammi visnaga on patients with pre-diabetes. All participants in the present study voluntarily participated, and agreed to use this prescription with weekly monitoring for their glucose levels. No nutritional restrictions were followed.

Study sample: Study sample included 5 patients with prediabetes, 2 females and 3 males.

Study procedure: Patients were suggested to use the aqueous extract of Ammi visnaga, 200 ml/daily for two months. At the beginning and the end of the experiment, in addition to weakly monitoring of glucose levels were taken, the BMI was calculated for each patient.

Statistical analysis: The analysis of data was carried out using SPSS version 21. Descriptive statistics were used to describe data. The collected data was presented in terms of means and standard deviation. The relationships between variables was determined based on independent T test. Significance was considered at α≤0.05.

Results

As demonstrated in Table 1, the mean age of the patients was 42±18.5years, 60% of patients were males. The mean level of glucose was 128±32mg/dl. The mean of BMI was 28±7.8kg/m². As seen in Table 2, there were significant changes in the levels of glucose and BMI. Glucose levels significantly decreased from 128±32mg/dl to 88mg/dl (p<0.05). The levels of BMI were significantly decreased (p<0.05) from 88±7.8 to 22±6.4kg/m².

Variable	Description
Age (M±SD) years	42±18.5 years
Gender (N, %):
- Male	3 (60%)
- Female	2 (40%)
Glucose (M±SD) mg/dl	128±32
BMI (M±SD) kg/m²	28±7.8 kg/m2

Table 1 Study variables in the beginning of the study

Variable	M	SD	P value
Glucose-before	128	32	<0.05
Glucose-after	88	12.5
BMI-before	28	7.8	<0.05
BMI-after	22	6.4

Table 2 The relationships between study variables before and after the experiment

Discussion

We have previously shown that pre-diabetic conditions can be treated and reversed to physiological level using rat models by the using of Urtica pilllifera.¹² We also found that pre-diabetes can be reversed by the using of tadalafil 5 mg/daily.¹³The present study showed that another herbal treatment, Ammi visnaga, can be used to treat pre-diabetic conditions. We think that it can exert their effects by two mechanisms. The first mechanism is mediated through the antioxidant’s effect.¹⁴ The second mechanism is through decreasing lipid levels such as cholesterol and triglycerides as reported in other studies.¹⁵Using rat model, we previously found that molecular defects in the brain white matter were beyond the events involved in the development of diabetes.¹⁶ We also found similar effects on liver induced by anti-oxidants.¹⁷The impacts of using Ammi visnaga in reducing weight were apparent in significantly lowering the levels of BMI. BMI is a good indicator of health since it determines normal weight, overweight, and obesity.¹⁸

Conclusion

The present study demonstrated that pre-diabetes is a very important situation and can be controlled to prevent the development of full episodes of diabetes, and it can be reversed to physiological conditions. Ammi visnaga is a herb with therapeutically beneficial effects to control diabetes.

Study limitations

The study gave a clue to early control diabetes, but the number of participants limited the possibility of generalizing the results. Other limitations included investigating other biochemical tests including lipid profile, liver function tests, and kidney function tests.