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Research Article Volume 15 Issue 1
The significance of gut microbiota controlling of epigenetic modifications in obesity with its therapeutic impact: a narrative review
Kulvinder Kochar Kaur, Gautam Nand Allahbadia, Mandeep Singh
Received: January 31, 2025 | Published: February 25, 2025
Citation: Kaur KK, Allahbadia GN, Singh M. The significance of gut microbiota controlling of epigenetic modifications in obesity with its therapeutic impact: a narrative review. ,Adv Obes Weight Manag Control. 2025;15(1):1-10 DOI: 10.15406/aowmc.2025.15.00413
Abstract
The global prevalence of obesity has reached epidemic proportions, significantly escalating the predisposition to various cardio metabolic disorders and some kinds of cancer, as reviewed by us on the role of gut microbiota (GM) in obesity generation basically through controlling variable kind of metabolic events. As per recent scientific research epigenetic modifications might work in the form of critical pathways via which GM and their metabolites aid in etio-pathogenesis of obesity and associated metabolic conditions. Thereby getting insight in the close cross talk amongst GM and epigenetic mechanistic modes is critical to display influence of obesity on the host. Apart from resulting in metabolic aberrations for instance insulin resistance (IR), escalated blood glucose, lipids, ectopic fat accrual, obesity further possess the capacity of causing injury to pancreatic islet cells, endothelial cells and cardiomyocytes via chronic inflammation, further facilitating generation of a microenvironment which aids in cancer initiation. Thus here in this review we basically concentrate on the association of GM and their microbial metabolites with epigenetic mechanistic modes in above cited comorbidities inclusive of energy disequilibrium, metabolic inflammation, and maternal inheritance. Further incorrect dietary habits and absence of physical exercise are significant behavioural factors which escalate the risk of obesity, that possess the capacity of influencing gene expression via epigenetic modifications. Actually here a summary of the studies on the manner probiotics, prebiotics along with other modulators that are capable of impacting GM constitution and affecting epigenetic mechanistic modes are detailed. Epigenetic alterations might take place in early stage of obesity, certain of which are reversible, whereas others continue with time along with result in obesity‐associated complications. Thereby, the dynamic adjustability of epigenetic modifications might be bargained for reverting the generation of obesity‐ correlated diseases via behavioural interventions, drugs, and bariatric surgery.
Keywords: obesity, gut micro biota (GM), microbial metabolites; epigenetic modifications, probiotics, prebiotics, FMT
©2025 Kaur, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.
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