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Review Article Volume 16 Issue 1
Strategies for exercise intervention in obesity: an integrated perspective from molecular mechanisms to public health implementation
Xiujuan Liu, Yawen Zheng
Received: February 27, 2026 | Published: June 3, 2026
Citation: Liu X, Zheng Y. Strategies for exercise intervention in obesity: an integrated perspective from molecular mechanisms to public health implementation. Adv Obes Weight Manag Control. 2026;16(1):16-22 DOI: 10.15406/aowmc.2026.16.00420
Abstract
Obesity and its associated complications have emerged as a significant global public health challenge, placing substantial strain on healthcare systems worldwide. As a cost-effective and non-pharmacological strategy, exercise intervention has evolved from generalized recommendations to precise, individualized, and scalable approaches within obesity prevention and management frameworks. This article provides a systematic review of recent advances in exercise-based interventions for obesity, with an in-depth analysis across four key dimensions: novel insights into molecular mechanisms, optimization of personalized precision exercise prescriptions, public health implementation strategies, and considerations for special populations. Specifically, newly identified molecular pathways such as the FOXO1-KLF10 feedback loop and the CD47 signaling target are discussed in detail. Furthermore, evidence-based precision strategies –including optimized combinations of maximal fat oxidation intensity (FATmax) training, high-intensity interval training (HIIT), and moderate-intensity continuous training (MICT), as well as synergistic interventions combining exercise with intermittent fasting –are critically examined. The paper also highlights practical experiences from national-level science and technology initiatives that leverage artificial intelligence and interdisciplinary collaboration to innovate obesity prevention and control. By integrating cutting-edge scientific evidence with actionable insights, this review aims to offer clinicians and public health professionals a comprehensive and practically relevant framework for implementing effective exercise interventions.
Keywords: obesity,exercise intervention,precision prescription, molecular mechanism,public health,fatmax
©2026 Liu, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.
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