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Mini Review Volume 4 Issue 4
Neurotrophins and childhood obesity
Parinaz Kalejahi
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Department of Nutrition, Tabriz University of Medical Sciences, Iran
Correspondence: Parinaz kalejahi, Department of Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Attar Nishabouri St., Tabriz, I. R. Iran, Tel 989143040656, Fax 84133340634
Received: October 20, 2015 | Published: April 19, 2016
Citation: Kalejahi P. Neurotrophins and childhood obesity. Adv Obes Weight Manag Control. 2016;4(4):99. DOI: 10.15406/aowmc.2016.04.00094
Abstract
Obesity in children is a global health problem and has been a rising trend in recent decades. Identify factors that contribute to childhood obesity, including neurotrophin that studied in recent years would be appropriate to intervene in order to prevent and control obesity. Brain-derived neurotrophic factor (BDNF) is the most important neurotrophin in obesity and is decreased in obese children than in healthy children.
Keywords: obesity, children, neurotrophin
Introduction
Obesity in children is a global health problem and has been a rising trend in recent decades. Multiple complications of obesity can be constant threat to the individual and society. Identify factors that contribute to childhood obesity, including neurotrophin that studied in recent years would be appropriate to intervene in order to prevent and control obesity. Nineteen related articles using keywords obesity, children, neurotrophin were selected. Brain-derived neurotrophic factor (BDNF) is the most important neurotrophin raised in obesity. BDNF can regulate food intake, energy homeostasis and affect weight control. The inverse relationship between plasma levels of BDNF and obesity in children was seen in most studies, and on the other hand the genotypes of the Val66Met polymorphism of the BDNF gene was associated with obesity and hyperphagia and also impaired of BDNF receptor (TrkB) in children was related with severe obesity.1–3
Conclusion
There was a significant decreased in plasma BDNF levels in obese children than in healthy children, and may be drugs acting on enhancement of BDNF activity will help in Prevention of Obesity.
Acknowledgements
None.
Conflict of interest
The author declares no conflict of interest.
References
- El–Gharbawy AH, Adler–Wailes DC, Mirch MC, et al. Serum brain–derived neurotrophic factor concentrations in lean and overweight children and adolescents. J Clin Endocrinol Metab. 2006;91(9):3548–3552.
- Friedel S, Horro FF, Wermter AK, et al. Mutation screen of the brain derived neurotrophic factor gene (BDNF): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention‐deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2005;132(1):96–99.
- Iughetti L, Casarosa E, Predieri B, et al. Plasma brain–derived neurotrophic factor concentrations in children and adolescents. Neuropeptides. 2011;45(3):205–211.
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