Editorial Volume 7 Issue 4
Eye as the First Manifestation Place of Various Systemical Diseases
Burak Turgut
Regret for the inconvenience: we are taking measures to prevent fraudulent form submissions by extractors and page crawlers. Please type the correct Captcha word to see email ID.
Department of Ophthalmology, Yuksek Ihtisas University, Turkey
Correspondence: Burak Turgut, Professor of Ophthalmology, Department of Ophthalmology, Faculty of Medicine, YuksekIhtisas University, 06520, Ankara, Turkey, Tel +90-312-2803601
Received: October 03, 2017 | Published: October 3, 2017
Citation: Turgut B (2017) Eye as the First Manifestation Place of Various Systemical Diseases. Adv Ophthalmol Vis Syst 7(4): 00230. DOI: 10.15406/aovs.2017.07.00230
Download PDF
Editorial
The eye is often involved in systemic diseases and even, eye may be the first manifestation place of a systemic disease. Some patients having a systemic disease do not awake for their diseases and do not know that they have these diseases because they do not like to be examined by a doctor until the disease affects their daily tasks and life quality. The eyes are actually not only the mirror of the heart but also whole body.1 Additionally, ocular changes may precede various systemic diseases. To know or aware the ocular signs as the first and common manifestation place of systemical diseases can allow to the physicians to quick reflection to relevant medical branch for screening and research of the presence of the suspected systemical disease. So, this can assist to diagnose the disease in early stages and to prevent serious complications due to the sytemical disease.
In this context, some systemic diseases and syndromes, which ocular manifestations might diagnose,2–9 are as follow:
- Hyperviscosity with tortuosity and occlusion in retinal vessels
- Myaesthenia gravis with ptosis and diplopia
- Hyperlipidaemia with xanthelasma, arcus juvenilis in corneaand presenile cataract
- Marfan’s syndrome with ectopialentis (lens subluxation or dislocation), keratoconus andretinal detachment
- Anaemia with retinal haemorrhage, Roth spot and cotton wool spot
- Leukaemia and lymphoma with orbital disease, uveitis, retinitis and optic nerve infiltration
- Atherosclerosis with arteriolar attenuation and vascular compression signs
- Malignant hypertension with retinal haemorrhages, hard exudates and cotton wool spots and optic disc edema
- Neurofibromatosis (type 1) with eyelid neurofibromas and Lisch nodules on the iris
- von Hippel-Lindau disease with retinal capillary haemangioma
- Temporal arteritis with anterior ischemic optic neuropathy and retinal vessel occlusion
- Grave’s Disease with bilateral exophthalmos and diplopia
- Behçet Disease with nongranulomatous uveitis and retinal vasculitis
- Diabetic retinopathy with diplopia and extraocular muscle palsy
- Romatoidartritis with dry eye syndrome and necrotizing scleritis
- Juvenile rheumatoid arthritis with uveitis and secondary (uveitic) glaucoma
- Sjögren’s syndrome with dry-eye and keratoconjunctivitis sicca.
Conclusion
The eye may be the first manifestation place of various systemical diseases. Thus, the eye is a special organ.
Acknowledgments
Conflicts of interest
There are no conflicts of interest.
Funding
References
- Duprez DA. The eye, the mirror of the heart. Eur Heart J. 2007;28(16):1915–1916.
- Urrets-Zavalía JA, Espósito E, Garay I, et al. The eye and the skin in nonendocrine metabolic disorders. Clin Dermatol. 2016;34(2):166–182.
- Lenake M, Du Toit N. The eye in systemic disease. S Afr Fam Pract. 2014;56(1):8–14.
- Şimşek HC, Akkoyun İ, Yılmaz G. Ophthalmic Manifestation of Hematologic Disesases. (Hematolojik Hastalıklarda Göz Bulguları). Ret-Vit. 2014;22(2):85–92.
- Hazin R, Lum F, Daoud YJ. Ophthalmic features of systemic diseases. Ann Med. 2012;44(3):242–252.
- Patel SJ, Lundy DC. Ocular manifestations of autoimmune disease. Am Fam Physician. 2002;66(6):991–998.
- Barra C, Belfort Junior R, Abreu MT, et al. Behcet’s disease in Brazil-A review of 49 cases with emphasis on ophthalmic manifestations. Jpn J Ophthalmol. 1991;35(3):339–346.
- Fujita M, Igarashi T, Kurai T, et al. Correlation between dry eye and rheumatoid arthritis activity. Am J Ophthalmol. 2005;140(5):808–813.
- Mohsenin A, Huang JJ. Ocular manifestations of systemic inflammatory diseases. Conn Med. 2012;76(9):533–544.
©2017 Turgut. This is an open access article distributed under the terms of the,
which
permits unrestricted use, distribution, and build upon your work non-commercially.