Advances in
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Opinion Volume 16 Issue 1
Cloverleaf geographical atrophy in age-related macular degeneration
Charu Gupta, Sandeep Kumar, Daraius Shrorff
Received: March 23, 2026 | Published: April 3, 2026
Citation: GuptaC, Kumar S, Shroff D. Cloverleaf geographical atrophy in age-related macular degeneration. Adv Ophthalmol Vis Syst. 2026;16(1):33-34. DOI: 10.15406/aovs.2026.16.00505
Abstract
Age-related macular degeneration (AMD) is a leading cause of visual impairment, with the dry form often progressing to geographic atrophy due to retinal pigment epithelium (RPE) loss. Fundus autofluorescence (FAF) provides a non-invasive window into RPE health and disease progression. We report a 73-year-old man with a gradual, painless visual decline, in whom wide-field FAF revealed a distinctive cloverleaf pattern of hypoautofluorescence corresponding to areas of atrophy, with surrounding reticular changes suggestive of RPE dysfunction. This case highlights the value of FAF in identifying characteristic atrophic patterns and underscores its role in monitoring disease progression in dry AMD in a clinically meaningful and patient-friendly manner
Keywords: ARMD, autofluorescence, geographical atrophy, retinal pigment
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