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Editorial Volume 8 Issue 3
Post-Acute-COVID-19-illness renal sequelae
Attapon Cheepsattayakorn,
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Ruangrong Cheepsattayakorn, Porntep Siriwanarangsun
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Correspondence: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, 143 Sridornchai Road Changklan Muang Chiang Mai 50100, Thailand
Received: June 12, 2021 | Published: July 23, 2021
Citation: Cheepsattayakorn A, Cheepsattayakorn R, Siriwanarangsun P. Post-Acute-COVID-19-illness renal sequelae. J Lung Pulm Respir Res. 2021;8(3):94. DOI: 10.15406/jlprr.2021.08.00258
Renal biopsies and autopsies in COVID-19-associated nephropathy (COVAN) patients revealed characteristically collapsing variant of focal segmental glomerulosclerosis, accompanying involution of the glomerular tuft and acute tubular injury in response to the activation of the chemokine and interferon,1-4 in addition to renal microcirculation thrombi.5 In acute-kidney-injury-susceptible COVID-19 patients, SARS-CoV-2 acts as a second hit that is similar to HIV and other virus.3 In hospitalized-COVID-19 patients and mechanical-ventilation-required-critically-ill-COVID-19 patients, severe acute kidney injury (AKI) requiring renal replacement therapy (RRT) occurs in approximately 5 % and 20 %-31 %, respectively.6-9 Short-term follow-up in several previous early studies in RRT-required patients demonstrated that around 27 %-64 % of them were dialysis independent by 28 days or ICU discharge.8,10 At 6 months after acute-COVID-19 phase in the post-acute-COVID-19 Chinese study, around 35 % of patients revealed reduction of the estimated glomerular filtration rate (eGFR; < 90 ml/min per 1.73 m2) and 13 % of them developed new-onset decrease of eGFR after revealed normal eGFR during acute COVID-19 phase.11 Approximately, 84 % of the COVID-19 survivors demonstrated renal recovery and a survival probability of 0.46 at 60 day following the acute COVID-19 phase.9 AKI survivor clinics will provide the benefits to COVID-19 survivors with persistent impaired renal function.12,13
In conclusion, COVID-19 survivors with persistent impaired renal function should be early and close followed up in post-acute-COVID-19 AKI clinics.
References
- Golmai P. Histopathologic and ultrastructural findings in postmortem kidney biopsy material in 12 patients with AKI and COVID-19. J Am Soc Nephrol. 2020;31(9):1944‒1947.
- Santoriello D. Postmortem kidney pathology findings in patients with COVID-19. J Am Soc Nephrol. 2020;31(9):2158‒2167.
- Velez JCQ, Caza T, Larsen CP. COVAN is the new HIVAN : the re-emergence of collapsing glomerulopathy with COVID-19. Nat Rev Nephrol. 2020;16(10):565‒567.
- Peleg Y. Acute kidney injury due to collapsing glomerulopathy following COVID-19 infection. Kidney Int Rep. 2020;5(6):940‒945.
- Jhaveri KD. Thrombotic microangiopathy in a patient with COVID-19. Kidney Int. 2020;98(2):509‒512.
- Robbin-Juarez SY. Outcomes for patients with COVID-19 and acute kidney injury : a systematic review and meta-analysis. Kidney Int Rep. 2020;5(8):1149‒1160.
- Commings MJ. Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City : a prospective cohort study. Lancet. 2020;395(10239):1763‒1770.
- Gupta S. Factors associated with death in critically ill patients with coronavirus disease 2019 in the US. JAMA Intern Med. 2020;180(11):1‒12.
- Steven JS. High rate of renal recovery in survivors of COVID-19 associated acute renal failure requiring renal replacement therapy. PLoS ONE. 2020;15(12):e0244131.
- Wilbers TJ, Koning MV. Renal replacement therapy in critically ill patients with COVID-19: a retrospective study investigating mortality, renal recovery and filter lifetime. J Crit Care. 2020;60:103‒105.
- Huang C. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021;397(10270):220‒232.
- Harel Z. Nephrologist follow-up improves all-cause mortality of severe acute kidney injury survivors. Kidney Int. 2013;83:901‒908.
- Suwanwongse K, Shabarek N. Newly diagnosed diabetes mellitus, DKA, and COVID-19 : causality or coincidence? : a report of three cases. J Med Virol. 2021;93(2):1150‒1153.
©2021 Cheepsattayakorn, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.
Citations
November is Lung Cancer Awareness Month, a vital opportunity for us to raise awareness about the dangers of lung cancer. Let’s unite to educate ourselves and others, and inspire proactive steps toward lung health. This year the motto of this event is “Stronger Together: United for Lung Cancer Awareness”. So for this occasion, the Journal of Lung, Pulmonary & Respiratory Research invites articles that emphasize the significance of lung protection. All the submissions received in the month of November will be offered with 40% discount on publication.