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eISSN: 2376-0060

Lung, Pulmonary & Respiratory Research

Editorial Volume 1 Issue 1

Hematological manifestations in patients with newly diagnosed pulmonary tuberculosis

Attaponÿ Cheepsattayakorn,1 Ruangrong Cheepsattayakorn2

1Department of Disease Control, 10th Zonal Tuberculosis and Chest Disease Center, Thailand
2Department of Pathology, Chiang Mai University, Thailand

Correspondence: Attapon Cheepsattayakorn, Department of Disease Control, 143 Sridornchai Road Changklan Muang, Chiang Mai 50100, Thailand, Tel 66-53-140767, Fax 66-53-140773

Received: August 22, 2014 | Published: August 23, 2014

Citation: Cheepsattayakorn A, Cheepsattayakorn R. Hematological manifestations in patients with newly diagnosed pulmonary tuberculosis. J Lung Pulm Respir Res. 2014;1(1):22–23. DOI: 10.15406/jlprr.2014.01.00005

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Introduction

Tuberculosis (TB), particularly TB is still a major public health problem of the world. Pulmonary eosinophilia,1,2 Hypereosinophilia,3 Reactivethrombocytosis,4–6 Thrombocytopenia,7 Disseminated intravascular coagulation,8 Deep venous thrombosis,9 Henoch-Schonlein purpura,10–12 Leukocytosis with neutrophilia,7,13 Lymphocytopenia,11,14 Monocytopenia, Lymphocytosis, Monocytosis,7 Severe leucopenia,7,15 Idiopathic thrombocytopenic purpura,16,17 Pancytopenia7,13,18 Could be found in patients with newly diagnosed pulmonary TB.

Hereditary glucose-6-phosphate dehydrogenase deficiency and pulmonary tuberculosis

A study in Azerbaijan, a state of former Soviet Union demonstrated that the etiological role of this abnormality as a genetic marker for pulmonary TB was 14% in associated pulmonary tuberculosis and alcoholism, it grew to 18%.19 Another study in this region also showed a high incidence of this hereditary disorder among patients with pulmonary TB.20

Hematological malignancies and pulmonary tuberculosis

Pulmonary military TB have been reported among patients with acute myeloid leukemia, chronic myeloid leukemia, acute lymphocytic leukemia, Hodgkin’s disease, T-cell lymphoma and myelodysplastic syndrome.21–23

Sickle cell disease and tuberculosis

Sickle cell disease was reported in patients with TB in France and Africa.24–26 Many reports suggest that severe pulmonary TB in association with reduced tissue cellular reaction may cause blood dyscrasias. Anemia was present in 32% of cases. Leucopenia with neutropenia and lymphopenia was seen in 15% of patients with very severe clinical TB. Active tuberculosis was associated with significant reductions in absolute numbers of B lymphocytes, but there were no significant differences in total T8-cell counts.15 There was reversal of T4//T8 ratio due to T4 lymphopenia. A study in Nigeria showed that 95% had normochromic picture while 5% demonstrated anisopoikilocytosis and polychromasia. The mean platelet counts did not change significantly from the initial value.27

Acknowledgements

None.

Conflict of interest

The author declares no conflict of interest.

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