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eISSN: 2473-0831

Analytical & Pharmaceutical Research

Mini Review Volume 5 Issue 1

Schiff’s Bases Metal Complexes in Biological Applications

Ajaykumar D Kulkarni

Correspondence: Ajaykumar D Kulkarni, Department of Applied Sciences, MIT Academy of Engineering (An Autonomous Institute Af?liated to Savitribai Phule Pune University), Dehu Phata, Alandi (D), Pune, 412105, India

Received: May 23, 2017 | Published: June 7, 2017

Citation: Kulkarni AD (2017) Schiff’s Bases Metal complexes in Biological Applications. J Anal Pharm Res 5(1): 00127. DOI: 10.15406/japlr.2017.05.00127

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Abstract

The article gives an insight into the use of Schiff’s bases as the ligand for the synthesis of various metal complexes. The coordination chemistry is dominated by the utilization of Schiff’s bases as ligands in the study of metal complexes. Further these metal complexes are used extensively in biological field along with many other applications. Several metal complexes of schiff’s bases have been used as antimicrobial agents, DNA cleaving agents, as sensors etc. Thus a glimpse of such several applications has been provided in this article.

Keywords:schiff’s bases, metal complexes, chemistry, antimicrobial, DNA cleaving agents

Mini review

“The Ever Increasing Applications of Metal Complexes in Various Fields of Science is the Driving Force for the Research and Development in Coordination Chemistry”

Coordination chemistry was founded by Swiss scientist A. Werner (1866-1919), who won the Nobel Prize in 1913. Great contribution was further made by Russian chemist L.A. Chugaev (1873-1922). Coordination (complex) entities consist of a cationic, anionic or neutral complex. Those substances, whose molecules contain a central atom (cations), coordinated with ligands (anions, neutral molecules or radicals) can be considered as coordination or complex entities1 and the area of inorganic chemistry, studying joint behavior of cations and their ligands was termed as coordination chemistry.2

The main direction of metal-complex chemistry in 21st century is emphasized as “From Biology to Nanotechnology”.3 ß-Diketones and their analogues, diketonate complexes,4 azomethinic and heterocyclic ligands remain “eternal”. Creation of new hard-soft ligand systems is attractive.5–8 Creation of hybrid biologically perspective ligating systems is also interesting.9–13 The principal goal is to work not only for theoretical, but also for practically useful coordination chemistry (competitive coordination), taking into account an operated creation of polyfunctional materials (for instance, selective electrodes). Modern achievements in coordination chemistry are detailed.14

Coordination chemistry is dominated by the utilization of Schiff bases as ligands15 due to its chelating ability and complexing ability towards transition metal ions. Schiff base compounds containing imine group (-RC=N-) are usually formed by the condensation of a primary amine/diamine with an active carbonyl compound. The Schiff base ligands and their complexes have significant importance in chemistry, and every year a number of reports are published on the preparation of these compounds and their application in chemical reactions.16 The Schiff base compounds and their complexes are widely applied in enantioselective cyclopropanation of styrenes,17 asymmetric addition of cyanide to aldehydes18 asymmetric aziridination of olefins,19 enantioselective epoxidation,19,20 regio-selective ring opening of epoxides21 and as a membrane in ion selective electrode.22-26 The metal complexes of Schiff bases also finds applications in versatile catalytic reactions for organic synthesis,27-30 degradation of organic substances31 in radiopharmaceuticals,32 their ability to reversibly bind oxygen33 and photochromic properties.34 Schiff base metal complexes have also found greater applications in biological field. Schiff bases have been reported to exhibit a variety of biological actions by virtue of the azomethine linkage, which is responsible for various antibacterial, antifungal, herbicidal, clinical and analytical activities.35–38 Recently, there has been tremendous interest in studies related to the interaction of transition metal ions with nucleic acid because of their relevance in the development of new reagents for biotechnology and medicine.39 There has also been substantial interest in the rational design of novel transition metal complexes, which bind and cleave duplex DNA with high sequence and structure selectivity.40-42

Acknowledgments

None.

Conflicts of interest

The authors declare no conflicts of interest related to this article.

Funding

None.

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