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Letter to Editor Volume 4 Issue 4
Papilloma vs. condyloma-a subtle distinction
Onat Y Akin1
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1PATOMED Pathology Laboratory, Istanbul, Turkey
1PATOMED Pathology Laboratory, Istanbul, Turkey
Correspondence: Onat Y Akin, PATOMED Pathology Laboratory, Darulaceze cad. No: 36/4 Okmeydani- Istanbul- Turkey, Tel +90 212 234 1712
Received: April 26, 2016 | Published: April 27, 2017
Citation: Akin OY. Papilloma vs. condyloma- a subtle distinction. Int Clin Pathol J. 2017;4(4):96. DOI: 10.15406/icpjl.2017.04.00103
Letter to editor
The dermatologists not very uncommonly submit lesions from the genital areas with a clinical diagnosis of condyloma acuminate. However, as pathologists trying to adhere to the well-defined criteria of these lesions, we may be reluctant to confirm that diagnosis due to absence of koilocytes. In such cases we may be designating these lesions as epidermal nevi, verruca vulgaris or merely as squamous papillomas depending on their morphology.
The importance of the lesion depends on a previous encounter and infection by certain HPV types and hence different prognoses. A squamous papilloma has HPV types 6 and 11 in 67% of the cases, whereas condyloma accuminatum has the same types in 90% of the cases. Both lesions under microscopic examination reveal varying degrees of papillomatosis, acanthosis and hyperkeratosis. However, the distinction of the two conditions will rely on koilocytotic cells that are present in condyloma accuminatum and this finding will make the condition severe because of the possibility of progression to dysplasia and eventually to cancer. On the other hand it appears that a squamous papilloma is an HPV-infected lesion that is underdeveloped and has not yet transformed into a picture of a condyloma so that the risk of developing cancer is virtually none. The sensitivity of the distinction of these two morphological diagnoses concerns the future follow-up of the patient for reasons of safety and therefore must be made with caution.
Acknowledgements
None.
Conflict of interest
The author declares no conflict of interest.
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