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Editorial Volume 2 Issue 1
Correlation of P16 expression and the clinicopathologic presentation of anal squamous cell carcinoma
Khurana H,1 Bedeir A,1 Samaha S1
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1Medical director, Aloha lab, USA
1Medical director, Aloha lab, USA
Correspondence: Samaha S, Medical director, Aloha lab, USA, Tel 480-577-1145
Received: January 28, 2016 | Published: February 15, 2016
Citation: Khurana H, Bedeir A, Samaha S. Correlation of P16 expression and the clinicopathologic presentation of anal squamous cell carcinoma. Int Clin Pathol J. 2016;2(1):23. DOI: 10.15406/icpjl.2016.02.00031
Editorial
Background
Many studies have shown a strong association between human papilloma virus (HPV) and anal squamous cell carcinoma (ASCC). Recent studies have also shown that HPV- related squamous cell carcinoma typically show abnormal overexpression of P16 (INK4a), which is detected by immunohistochemical (IHC) staining. In this study we will compare the clinicopathological features of p16 positive (p16+) and p16 negative (p16-) ASCC.
Design
The Miraca Life Sciences Data Warehouse was searched for cases with the diagnosis of ASCC on anal biopsies diagnosed between 1/1/2009 and 6/1/2011. The first 50 consecutive cases were included in this study. Original H&E stained slides were retrieved. The slides were reviewed by 3 pathologists and a representative block was selected for P16 immunohistochemical analysis. Pertinent clinical and pathologic details were gathered.
Results
Results are shown in Table 1
|
P16 (+) ASCC |
P16 (- )ASCC |
|
Number of patients |
43 (86%) |
7(14%) |
|
Gender |
|
|
|
Male |
11 |
3 |
|
Female |
32 |
4 |
|
Female: Male |
2.9:1 |
1.3:1 |
|
Age |
|
|
|
Range |
47-84 |
54-91 |
|
Mean |
63.6 |
74.8 |
|
Grade |
|
|
|
Moderately differentiated |
20 (46.5%) |
7(100%) |
|
Poorly differentiated (including Basaloid ) |
23 (53.5%) |
0 |
P= 0.0113 |
Table 1 P16 expression in ASCC.
Conclusion
P16+ASCC represented the majority of ASSC (86%). This group of patients had a female predominance and a wide range for age of presentation (47-84, mean=63.6). Patients with P16 (-) ASCC represent only 14% of cases. They presented at older age (54-91, mean=74.8) and showed almost equal gender distribution. Interestingly, poorly differentiated ASCC was only seen in p16+ASCC and represented 53.5% of this group.
Acknowledgements
None.
Conflict of interest
The author declares no conflict of interest.
©2016 Khurana, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.