Advances in ISSN: 2377-4290 AOVS

Ophthalmology & Visual System
Volume 6 Issue 6 - 2017
The Importance of VRI and AOR Segmentations in Optical Coherence Tomography Angiography
Department of Ophthalmology, Firat University, Turkey
Received: April 21, 2017 | Published: April 24, 2017
*Corresponding author: Burak Turgut, Associate Professor of Ophthalmology, Firat University, Faculty of Medicine, Department of Ophthalmology, 23119, Elazig, Turkey, Tel: +904242333555; Fax: +904242388096; E-mail: ; ;
Citation: Turgut B (2017) The Importance of VRI and AOR Segmentations in Optical Coherence Tomography Angiography. Adv Ophthalmol Vis Syst 6(6): 00199. DOI: 10.15406/aovs.2017.06.00199


In this editorial, it was aimed to call attention to the importance of the screening and the evaluation of the segmentations of vitreoretinal interface and avascular outer retina in optical coherence tomography angiography for subclinical or early pre-retinal and choroidal neovascularization. In optical coherence tomography angiography of a healthy subject, both segmentations of vitreoretinal interface and avascular outer retina do not show obvious vascular structure. Thus, these two segmentations can be used for the screening of preretinal and choroidal neovascularization in various ischemic vascular diseases.

Keywords: Avascular outer retina; Choroidal neovascularization; Optical coherence tomography angiography; Vitreo-retinal interface; Pre-retinal neovascularization; Screening


OCTA: Optical Coherence Tomography Angiography; VRI: Vitreoretinal Interface; AOR: Avascular Outer Retina; PNV: Preretinal Neovascularization; OPL: Outer Plexiform Layer; CNV: Choroidal Neovascularization; RPE: Sub-retinal Pigment Epithelium


Optical coherence tomography angiography (OCTA) is a very useful angiography type for the evaluation of both retinal and choroidal vasculature. OCTA is noninvasive imaging method without adverse effects because the usage of a contrast agent is not needed in this imaging method. Using by OCTA, the vasculature and blood flow of retina and choroid can be visualized in detail through detecting motion contrast of erythrocytes in the vessel, using serial optical coherence tomography B-scans. OCTA has an ability to perform the separate segmentations including the vitreoretinal interface (VRI), the superficial retinal layer, the deep retinal layer, avascular outer retina (AOR), the choriocapillaris and the choroid (Figure 1) [1-8].

Figure 1: The segmentations in optical coherence tomography angiography. The images with red frames belong to the segmentations of vitreoretinal interface (VRI) and avascular outer retina.

In a healthy eye, the VRI has no vascular structure though the ganglion cell layer of the retina has the superficial retinal capillary plexus based on vitreo-retinal histology and VRI segmentation of OCTA (Figure 1, VRI) [1-8]. Preretinal neovascularization (PNV) is characterized by networks of vessels lying on the surface of the retina and invading the cortical vitreous gel and extending into the vitreous cavity. PNV usually occurs in the ischemic retinal vascular diseases such as proliferative diabetic retinopathy, retinal vein occlusion, retinopathy of prematurity and sickle-cell disease retinopathy [9-13]. PNV in earlier stages of the pathogenesis of abnormal neovascularization event may be overlooked. VRI segmentation of OCTA can be used to screen and detect the early or subclinical PNV in these diseases [9-12].

In the other hand, both the histological examinations and OCTA reports of retina in healthy subjects demonstrated that there is an avascular retinal region (avascular outer retina, AOR) in the deep or outer layer of the retina. AOR is the layer between the outer plexiform layer (OPL) in the inner border and ellipsoid zone in the outer border. The outer retina segmentation between the OPL and Bruch membrane by OCTA show no vascular blood flow in a normal eye (Figure 1, Avascular) [1-8]. Choroidal neovascularization (CNV) defines the development of the new blood vessels derived the choroid and the invasion into sub-retinal pigment epithelium (RPE) or subretinal space via a break in Bruch membrane. Type 1 choroidal neovascularization (CNV) is characterized by vessels proliferating under the RPE and it is found in the subretinal space. Type 1 CNV is also termed occult CNV because it can be poorly detected with dye-assisted angiography. In the OCT scans Type 1 CNV is observed as localized fusiform serous or fibro-vascular RPE detachment. Additionally, polypoidal choroidal vasculopathy is also considered as a variation of this type CNV [14,15]. In newly studies, it has been reported that OCTA provides more precisely and comprehensively describe of Type 1 CNV in AMD [16-19]. Thus, OCTA can also be used for early detection of an occult CNV (Type 1 CNV) in this AOR in the eyes with asymptomatic eyes in the stages of early or intermediate AMD.


The segmentations of VRI and AOR in OCTA have no any vascular neoformation and that of the observation in OCTA of a vascular structure in the segmentations of these segmentations may provide early detection any preretinal or choroidal NV, respectively.


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