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Urology & Nephrology Open Access Journal

Case Report Volume 2 Issue 2

Three cases of acute porphyria, presenting with severe hyponatremia

Elena V Zakharova

Nephrology, Moscow State University of Medicine and Dentistry, Russia

Correspondence: Elena Zakharova, State University of Medicine and Dentistry, City Clinical Hospital n.a. S.P. Botkin, 115284, 2-nd Botkinsky proezd, 5, Moscow, Russia, Tel 7 499 728 8291, Fax 7 495 945 1756

Received: February 02, 2015 | Published: April 1, 2015

Citation: Zakharova EV. Three cases of acute porphyria, presenting with severe hyponatremia. Urol Nephrol Open Access J. 2015;2(2):55-59. DOI: 10.15406/unoaj.2015.02.00034

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Abstract

Porphyrias are a group of rare metabolic diseases that result from enzymatic defects of porphyrins metabolism and heme synthesis. Accumulation of porphyrins and their precursors present with neuro-visceral symptoms and/or skin lesions. Acute porphyrias may have variety of manifestations; most common of them are abdominal pain and central nervous system disturbances, hyponatremia is highly characteristic for acute intermittent porphyria and is usually attributed to syndrome of inappropriate secretion of antidiuretic hormone (SIADH). We present here three cases of acute porphyria, primary diagnosed in ICU by nephrologist, invited for evaluation and treatment of severe hyponatremia and discuss causes of hyponatremia, differentiating between SIADH and cerebral salt wasting (CSW) syndrome.

Keywords: acute porphyria, clinical, electrolyte imbalance

Abbreviations

ALA, amino levulonic acid; AlAT, alanine amino transferase; AsAT, asparagine amino transferase; BP, blood pressure; Ca, calcium; CK, creatine phosphokinase; Cl, chloride; CSW, cerebral salt wasting; CT, computer tomography; ECG, electrocardiogram; ECHO-CG, echocardiography; Hb, hemoglobin; HPF, high power field; HR, heart rate; K, potassium; LDH, lactate dehydrogenase; LP, lumbar punction; Na, sodium; NSAID’s, nonsteroid anti-inflammatory drugs; O2 Sat, oxygen saturation; PBG, porphobilinogen; Plt, platelets; Posm, plasma osmolality; RBC, red blood cells; RR, respiratory rate; SIADH, syndrome of inappropriate secretion of antidiuretic hormone; SG, specific gravity; TB, total bilirubin; TBC, total blood count; TP, total protein; UTI, urinary tract infection; WBC, white blood cells

Introduction

The Porphyrias are a group of rare metabolic diseases that result from defects (genetic or, rarely, acquired) of enzymes needed at various steps of heme synthesis. As precursors of heme are porphyrins, deficiencies in any of enzymes, involved in their metabolism, may lead to the accumulation of porphyrins, presenting with distinct clinical syndromes- acute or chronic. Porphyrias are also classified into those predominantly involving the skin, those manifesting as disorders of the liver/nervous system, and a combination involving all 3 entities. Clinical manifestations depend on the particular enzymatic defects -if the defects are in the initial steps of the metabolic cascade, neurotoxic early metabolic intermediate products (i.e. amino Levulonic acid and Porphobilinogen) accumulate, resulting with attacks of neurologic dysfunction; if the defects are in the final steps, porphyrin accumulate in the skin causing photosensitivity. The acute porphyrias are characterized by periodic acute attacks of neurovisceral symptoms. This group include acute intermittent porphyria, the Doss porphyria, hereditary coproporphyria, and variegate porphyria. The chronic porphyrias (congenital erythropoietic porphyria, erythropoietic porphyria, and porphyria cutanea tarda) are dermatologic diseases that may or may not involve the liver and nervous system and do not present with acute attacks.1–3

Acute porphyria clinical presentation may include:

  1. Abdominal pain
  2. Constipation/diarrhoea
  3. Nausea/vomiting
  4. Arterial hypertension/tachycardia
  5. Fever
  6. Sweating
  7. Muscle weakness
  8. Tetra paresis
  9. Respiratory paralysis
  10. Limb pain
  11. Motor neuropathy
  12. Paresthesias/dysesthesias, numbness
  13. Cranial nerve involvement/blindness
  14. Tremor
  15. Seizures
  16. Urinary retention/incontinence, dysuria
  17. Aphasia/apraxia
  18. Psychosis
  19. Anxiety/restlessness
  20. Agitation
  21. Confusion/coma
  22. Depression/insomnia
  23. Skin rush
  24. Rhabdomyolysis
  25. Red/brown urine
  26. Elevated WBC count
  27. Hyponatremia

Acute intermittent porphyria is the most common and the most severe form of the inherited hepatic porphyrias, affecting mainly young women. Provoking factors are known to be alcohol ingestion, infection, surgical procedure, variety of drugs, low-carbohydrate diet or fasting and menstruation.4–11 We present three cases of newly diagnosed acute porphyria, presenting with severe hyponatremia in ICU.

Case 1

Nephrologist was invited to ICU to consult the patient with hyponatremia (Na 103mmol/l). Caucasian lady 29years old, day 6 in the hospital, day 2 in ICU.

Physical examination

Erythematosus face rash, lips red boarder bright, no edema, skin and mucous dry. Coma, motor excitement, adequate pain reaction, lack of swelling, normal cough reflex, widened pupils with normal photo reactivity. Body temperature 37.0°C, spontaneous respiration, RR 25 per minute, HR140 per minute, BP160/85 mm Hg. Heart and lung unremarkable, abdomen soft, non-tender. Stool after enema, normally colored, urination via ureteral catheter, urine colored reddish-brown, urine output 4800ml/day.

Workup

НB 15.6g/dl, WBC 12.9x10*6/mcl, Plt127x10*6/mcl, TP 6.2g/dl, TB 20mcmol/l, creatinine 66mcmol/l, urea 4,9mmol/l, uric acid 189mcmol/l, AsAT 137U/l, AlAT66 U/l, amylase 218U/l, CK 25899U/l, LDH 650 U/l, К 2.8mmol/l, Na 103mmol/l, Ca++ 0.97mmol/l, Cl 73mmol/l, Posm 214mosm/kg, рН 7.55, bicarbonate 25.3mmol/l, O2sat 91% at room air.

LP

Liquor colorless, transparent, protein 1.1g/l, neutrophil cytosis 15/3.

Urinalysis

Protein 0.5g/l, glucose-abs, WBC 3-4, RBC 1-2 HPF, bilirubin+++, urobilin+++.

Previous medical history

Unremarkable-nothing but normal pregnancy 5years ago. She was known to have respiratory symptoms, chill, fever (38.6°C) and myalgia6days before admission, and taking paracetamol and antibiotics. In two days respiratory symptoms resolved, but she experienced abdominal pain, vomiting, constipation, and noticed dark urine (Figure 1).

Figure 1 Case 1-dark urine.

Clinical course

3days later, with the same complains she was seen in ER of our hospital. Physical examination did not show anything significant. Workup, including standard labs, ECG, ultrasound, chest and abdomen plain X-ray, radio contrast kidney X-ray and laparoscopy found nothing but “reddish-brown” urine (protein 0.033g/l, RBC 70-80hpf), mild hyponatremia (133mmol/l), and sinus tachycardia. She was diagnosed with UTI, referred to urology unit and started with NSAID’s, antiemetic’s, spasmolytics, Ringer solution, cephalosporin's, antifungal and omeprazole.

Day 3 in the hospital fever resolved, but she complained for dysuria and severe back pain, which were interpreted as a consequence of her regular menses, Novocain was added to her treatment. Day 5 she was found depressive, and started with amitriptyline, the same night she developed seizures (treated with carbamazepine and diazepam), and coma. CT showed brain edema, and she was transferred to ICU and continued with diazepam, carbamazepine, omeprazole, cephalosporins and normal saline; potassium chloride and magnesium were added.

Diagnosis and follow-up

Day 6 (day 2 in the ICU) her neurologic status was unchanged, hemodynamics-stable, but respiratory distress worsened. Given skin lesions, abdomen pain and constipation, seizures, coma, dark urine, and hyponatremia-nephrologist suspected acute porphyria. High CK and LDH were attributed to rhabdomyolysis. Additional workup, including urine Ehrlich test for porphyrins was recommended, and it was advised to discontinue magnesium, antibiotic’s and anticonvulsant’s, and infuse NaCl 3% solution 1-2ml/kg/hour under serum sodium control, targeting sodium not higher than 115-116mmol/l at the end of first day.

Day 8 (day 4in ICU) patient’s condition improved. Spontaneous respiration, conscious, but confused, BP 140/80 mmHg, HR120 per minute. Plasma Na-122mmol/l, urine output 2600ml/24hours, urine still reddish-brown, and Ehrlich test-positive. Diagnosis of acute porphyria with first clinical manifestation after viral infection, menstruation, and NSAIDS, antibiotics and sedatives usage was confirmed. Day 10 (day 6 in ICU) she was stable, slightly confused, BP 135/85 mm Hg, HR 110 per minute. Plasma Na 129mmol/l, К 4.1mmol/l, Ca++ 1.28mmol/l, Cl 104mmol/l, рН 7.38. Patient was transferred to reference centre for Porphyrias.

Case 2

Nephrologist was invited to ICU to consult the patient with hyponatremia (serum Na 114mmol/l). Caucasian lady 30years old, day 10 in the hospital, day 2 in ICU.

Main complains

Weakness, pain in her neck, back and lower extremities and lower extremities numbness.

Physical examination

Lips red boarder bright, erythematous rush on her face, neck and upper extremities (Figure 2), no edema, skin and mucous dry. Conscious, slightly confused, no focal signs. Body temperature 37.2°C, spontaneous respiration, RR 20per minute, HR78per minute, BP150/80mm Hg. Heart and lung unremarkable, abdomen soft, non-tender. No stool. Spontaneous urination with red urine, urine output was 2500ml/day.

Figure 2 Case 2-skin rush.

Workup

Нв 14.0g/dl, WBC 9.8x10*6/mcl, Plt295x10*6/mcl, TP 6.6g/dl, albumin 3.6g/dl, TB 25mcmol/l, creatinine72mcmol/l, urea2,0mmol/l, AsAT53U/l, AlAT27 U/l, amylase117U/l, CK1324U/l, LDH257U/l, К2.3mmol/l, Na 114mmol/l, Cl84mmol/l, Posm 241mosm/kg, рН 7.56, bicarbonate30.6mmol/l, O2 sat100% at room air.

Urinalysis

Protein 0.7g/l, bilirubin 34mmol/l, urobilin 50mmol/l, WBC, RBC – 0-1hpf, urine osmolality 316mosm/kg.

Previous medical history

2 normal pregnancies 7 and 5years ago. 9 month before current episode, after taking vermicides (together with her kids who had seat worms), she developed severe abdominal pain and pain in lower extremities and was admitted to local hospital. She got laparotomy, which did not show any surgical disease. 3 months later she had another episode of abdominal pain, recognised as adhesive obstruction and resolved without surgery.

At the day of admission she developed abdominal pain and 6hours later was admitted to surgery unit of our hospital, suspected for appendicitis. Her vital signs were otherwise normal, abdomen soft and non-tender, slightly painful in epigastrium and right flank.

Clinical course

Normal TBC and blood chemistry but plasma Na 133mmol/l, and normal urinalysis. ECG showed sinus tachycardia. Abdomen and pelvic ultrasound and plain abdomen X-ray were normal, small bowel follow through showed ileocecal barium retention; she was diagnosed with adhesive obstruction and treated with normal saline, Ringer solution and spasmolytics.

Day 3 of hospital stay she still had diffuse abdominal pain and complained for pain in lower extremities, her vital signs, stool and urination were normal. TBC was normal with Hb 16.0g/dl, blood chemistry found TB 28 mcmol/l, creatinine 84mcmol/l, urea 2.2mmol/l, AsAT 66 U/l, Na 130mmol/l, K 4.2mmol/l, Cl 90mmol/l. Urinalysis: SG 1015, protein absent, bilirubin 8.5mmol/l, gastroscopy revealed reflux-gastritis, colonoscopy showed only dolychosigmoid. She was continued with normal saline, Ringer solution and spasmolytics, NSAID’s were added.

Day 7 of hospital stay she complained skin rush and developed agitation, neurologist did not find any focal signs and diagnosed neurotic reactions, sulpiride was added. Dermatologist diagnosed toxicodermia and recommended to continue crystalloid infusions. Day 9 of hospital stay her condition worsened, she complained of pain in her neck, back and lower extremities, found to be hypovolemic and confused, referred to ICU and continued with normal saline, Ringer solution, omeprazole and NSAID’s; cephalosporin’s, amino glycoside’s, calcium-channel blockers, beta-blockers, ACE-inhibitors, heparin and diazepam were added.

Diagnosis and follow-up

Day 10 (day 2 in ICU) her condition did not changed. Nephrologist, basing on 3 episodes of abdominal pain, laparotomy with uncertain diagnosis 9 months ago, skin rush, neck, back and low extremities pain, arterial hypertension and tachycardia, agitation, numbness, red urine and hyponatremia suspected acute porphyria. It was advised to perform urine Ehrlich test for porphyrins, discontinue antibiotics, heparin, diazepam, NSAID’s, anti-hypertensive’s, and infuse Glucose 40% 1000ml/day and NaCl 3% solution 1-2ml/kg/hour under serum sodium control, targeting sodium not higher than 125mmol/l at the end of first day.

Day 12 of hospital stay (day 4 in ICU) patient’s condition improved - conscious, alert, no focal signs, mild pain and numbness in lower extremities. Vital signs normal, urine output 2000ml/day. Normal stool. Plasma Na 129mmol/l, K 4.1mmol/l, CK 346 U/l. Ehrlich test positive. Diagnosis of acute porphyria was confirmed and patient was transferred to reference centre for Porphyrias.

Case 3

Nephrologist was invited to ICU to consult the patient with hyponatremia (serum Na 112mmol/l). Caucasian lady 39years old, day 4 in the hospital, day 2 in ICU. Sopor, no focal signs.

Physical examination

Erythematosus skin rush (Figure 3) and hyper pigmentation on upper extremities, no edema, skin and mucous dry. Body temperature 36.6°C, spontaneous respiration, RR 22per minute, HR80 per minute, BP135/80mm Hg. Lung and heart unremarkable, abdomen soft, not tender. No stool, urination via ureteral catheter, urine colored dark brown, and urine output 4300ml/day.

Figure 3 Case 2-skin rush.

Workup

НB 13.0g/dl, WBC 6.6x10*6/mcl, Plt 307x10*6/mcl, TP 6.5g/dl, TB 23mcmol/l, albumin 3.5g/dl, creatinine 81mcmol/l, urea 3,8mmol/l, AsAT 236U/l, AlAT 81U/l, amylase 102U/l, CK 9570U/l, LDH 379U/l, K 2.9mmol/l, Na 112mmol/l, Cl 85mmol/l, Posm 231mosm/kg, рН 7.49, bicarbonate 20.4mmol/l, O2 sat 100% at room air.

Urinalysis

SG 1015, protein abs, bilirubin 34mmol/l, urobilin 34mmol/l, WBC, RBC-absent. ECG showed sinus tachycardia and ST elevation in 2-nd standard lead, ECHO-CG revealed left ventricular dilatation and anteroseptal hypo kinesis with ejection fraction 42%.

Previous medical history

Normal pregnancy 14years ago, since that time she was taking oral contraceptives. 3years ago she had anepisode of abdominal pain; laparotomy did not show any surgical disease. 2 weeks before current admission she developed abdominal pain, was admitted to the surgery unit our hospital, complaining for constipation, and diagnosed with abdominal colic. Her vital signs were otherwise normal, abdomen, slightly painful but soft and non-tender. Workup showed normal TBC, blood chemistry revealed total bilirubin 40mmol/l, AsAT 166U/l, AlAT 98 U/l, cholesterol 8.3mmol/l, K 3.9mmol/l, Na 106mmol/l, other test were normal. Urinalysis was not performed. ECG, abdomen and kidney ultrasound, chest and abdomen plain X-ray, abdomen CT and colonoscopy were unremarkable. She was seen by neurologist and diagnosed with asthenia. She received spasmolytics and laxative’s, her condition improved and she was discharged on the 9-th day of hospital stay. Her blood chemistry abnormalities were not interpreted.

2days after discharge she was seen in ER of our hospital for severe abdominal pain, nausea, vomiting and dark urine. Her vital signs normal, abdomen soft and non-tender.

Clinical course

Hb 12.9g/dl, WBC 5.0x10*6/mcl, Plt 230x10*6/mcl, TB9 mcmol/l, creatinine 71mcmol/l, urea 2,6mmol/l, AsAT 84U/l, AlAT 57 U/l, amylase 157U/l, К4.8mmol/l, Na 129mmol/l, Ca++ 1.1mmol/l, Cl 100mmol/l; urinalysis: SG 1010, protein-abs, bilirubin 8.5mmol/l, WBC, RBS-abs. Plain chest, abdomen and kidneys X-ray, abdomen and kidneys ultrasound-otherwise normal but mild pancreatic hyperechogenicity. She was diagnosed with pancreatitis, referred to surgery unit and treated with normal saline, Ringer solution, NSAID’s, spasmolytics, cephalosporins and omeprazole.

Day 3 of hospital stay her condition worsened-she became disoriented, with agitation and psychomotor excitement. Brain CT did not show anything significant, she was diagnosed with “toxic psychosis”, referred to ICU and continued with normal saline, Ringer solution, NSAID’s, cephalosporin's and omeprazole; heparin was added.

Diagnosis and follow-up

Day 4 (day 2 in ICU) her vital signs were stable, but she became soporos. Nephrologist, basing on prolonged usage of oral contraceptives, laparotomy for uncertain indications 3years ago, abdominal pain, constipation, nausea, vomiting, psychosis and hyponatremia suspected acute porphyria. It was advised to perform urine test for porphyrins, discontinue antibiotics, NSAID’s and heparin, and infuse Glucose 40% 1000ml/day and NaCl 3% solution 1-2ml/kg/hour under serum sodium control, targeting sodium not higher than 120mmol/l at the end of first day.

Day 5 (day 3 in ICU) her condition improved-conscious, alert, no focal signs. Vital signs normal, urine output 6200ml/day. Stool after enema, normally coloured. Plasma Na 125mmol/l, K 4.7mmol/l, CK 1448 U/l, LDH 574 U/l. Urine test for porphyrins: Total porphyrins 0.29mg/l, PBG 81mg/ml, ALA 21mg/l. Diagnosis of acute porphyria was confirmed and patient was transferred to reference centre for Porphyrias.

Discussion

All three cases, we present here, show typical manifestations of acute porphyria with numerous abdominal and central nervous system symptoms, rhabdomyolysis, and coloured urine, and also with skin lesions in two cases. Female sex and young age, as well as trigger factors like infection, menstruation and various medications is very common in acute porphyria. Misdiagnosing, laparotomy and treatment with NSAID’s, antibiotics and sedatives, which lead to the deterioration of patients condition, is also characteristic for cases of acute intermittent porphyria before proper diagnosis is made.12–18

Marked hyponatremia, which is most common electrolyte imbalance in patients with neurologic diseases, frequently complicates acute porphyrias. Its mechanism is not fully understood, but SIADH, gastrointestinal losses, infusions of hypotonic dextrose-containing fluids, nephrotoxicity, excess renal sodium excretion, and damage to the supraoptic nuclei of the hypothalamus, has been implicated in its pathogenesis.16,17,19–27

We considered SIADH, but some clinical data could not be completely understood in this setting. SIADH is volume expanded status due to increased renal water reabsorption by excessive and inappropriate AVP secretion, often seen in patients with central nervous system diseases and hyponatremia. But many of these patients, who meet the diagnostic criteria for SIADH, have a volume status incompatible with that diagnosis. The evidence of volume depletion in these patients is more consistent with the diagnosis of CSW syndrome. CSW syndrome is characterized by excess renal sodium wasting with resulting volume depression. Although, the mechanism of CSW syndrome is not fully understood, the most possible hypothesis is central amplification of natriuretic peptides, especially brain natriuretic peptide, combined with decreased sympathetic outflow due to various neurologic diseases. SIADH and CSW syndrome are two main mechanisms of hyponatremia in patients with various neurologic diseases, excluding iatrogenic causes. Distinction between SIADH and CSW syndrome may be difficult due to overlapping laboratory findings and clinical presentations, the fundamental differences between these two entities are as follows: SIADH is in a volume expanded status due to inappropriately secreted AVP, however, CSW syndrome is in a volume depleted status characterized by renal sodium wasting and appropriate secretion of AVP.28–32

In our three patients plasma osmolality was decreased to 214, 241 and 231mosm/kg respectively, but they all were volume depleted, with dry skin and mucosa, hemoglobin normal or as high as 16.0g/dl, and urine output increased. Only one of our three patients had vomiting, not that much prolonged, and none of them were diarrheal. Also none got hypotonic glucose-containing infusions.

Conclusion

The main cause of severe hyponatremia in our patients was excess renal sodium excretion due to CWS syndrome, and we found only one case of similar findings explained by CSW syndrome in acute intermittent porphyria on Contemporary Pediatrics site: “A wild case of abdominal pain” by Georgy B Kenny.

Acknowledgements

None.

Conflict of interest

The author declares no conflict of interest.

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