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Nursing & Care Open Access Journal

Editorial Volume 8 Issue 3

Several approaches for anticancer drug development progress

Da-Yong Lu,1 Yi Lu2

1School of Life Sciences, Shanghai University, China
2Shanghai Ocean University, Shanghai, China

Correspondence: Da-Yong Lu, School of Life Sciences, Shanghai University, Shanghai200444, PR China

Received: November 01, 2022 | Published: November 8, 2022

Citation: Da-Yong L, Yi L. Several approaches for anticancer drug development progress. Nurse Care Open Acces J. 2022;8(3):85-86. DOI: 10.15406/ncoaj.2022.08.00244

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Abstract

Anticancer drug development is facing increasingly challenge. Much more chemicals or bio-agents are required to be evaluated every year. High-quality and speediness of drug evaluation requires joint-efforts between chemists and pharmacologists. This Editorial provides this area of anticancer drug discovery, development and licensing.

Keywords: anticancer drug development, phytochemistry, biotechnology, experimental models

Introduction

Cancer is a mystery malignant disease that costs life of 9.6 millions annually worldwide. Current cancer therapeutics is lack of effective anticancer drugs and drug selective systems in the clinic.1–5 over the past two decades, anticancer drug developments improved slowly.6–9 Several approaches can help drug evaluation and development.10–13 This Editorial discusses this important topic.

Methods

Major pathways

  1. Tumor model innovation.14
  2. Technical advances (3-dimentional cell culture, organoids, genetic-modified cells and others.15–19
  3. High-throughput and miniature screening.20–22
  4. Cancer metastatic models in vivo.23–28
  5. Nano-drugs or drug delivery.29–30
  6. Phytochemistry and herbal medicine.31–37
  7. Drug combination study (mechanisms and clinical strategies)38–40
  8. Personalized medicine or clinical drug selection and dosing.41–43
  9. Mathematical or computational supports.44–47
  10. Palliative therapeutics.48–50

Results and discussion

Above-mentioned pathways are important scientific disciplines for drug develop promotion. To do this drug development transition, hard pharmaceutical or pharmacological work is indispensable.51–53 Among this wide-range of topic, antimetastatic drug develop is the most important one because 60-90% cancer deaths come from neoplasm metastasis. Good selection and large scale in vivo drug evaluation is the important way. New pharmacological studies are the common interests and discipline for anticancer drug development.

Conclusion

To facilitate anticancer drug discovery and development, pharmacological updating can make a difference. But we shall have a long way to go.

Acknowledgments

None.

Conflicts of interest

None.

References

  1. Mina LA, Sledge GW. Rethinking the metastatic cascade as a therapeutic target. Nat Rev Clin Oncol. 2011;8(6):325–332.
  2. Lu DY, Lu TR, Xu B, et al. Anticancer drug developments, challenge from historic perspective. EC Pharmacology & Toxicology. 2018;6(11):922–936.
  3. Lu DY, Lu TR. Antimetastatic activities and mechanisms of bisdioxopiperazine compounds. Anticancer Agent Med Chem. 2010; 10(7):564–570.
  4. Lu DY, Lu TR, Cao S. Cancer metastases and clinical therapies. Cell & Developmental Biology. 2012;(4):110.
  5. Lu DY, Lu TR, Wu HY, et al. Cancer metastasis treatments. Current Drug Therapy. 2013;8(1):24–29.
  6. Merris J. Productivity counts—but the definition is key. Science. 2005;309(5735):726–727.
  7. Ruggeri BA, Camp F, Miknyoczki S. Animal models of disease: Preclinical animal models of cancer and their applications and utility in drug discovery. Biochem Pharmacol. 2014;87;150–161.
  8. Herter GS, Kung AL, Wong KK. New cast for a new era: preclinical cancer drug development revisited. J Clin Investigation. 2013;123(9):3639–3645.
  9. Lu DY, Lu TR. Anticancer drug development, challenge and dilemma. Nurs Care Open Access J. 2020;7(3):72–75.
  10. Lu DY, Xu B, Lu TR. Anticancer drug development, pharmacology update. EC Pharmacology & Toxicology. 2020;2:1–6.
  11. Lu DY, Chen EH, Lu TR. Anticancer drug development, a matter of money or a matter of idea? Metabolomics. 2015;5(2):134.
  12. Lu DY, Lu TR, Zhu H, et al. Anticancer drug development, getting out from bottleneck. Int J Mol Biol. 2017;2(1):28–33.
  13. Lu DY, Lu TR, Yarla NS, et al. Anticancer drug development, breakthroughs are waiting. Adv Pharmacol Clin Trials. 2017;2(1):119.
  14. Jelgersma C, Vajkoczy P. How to target spinal metastasis in experimental research: An overview of currently used experimental mouse model and future prospects. Int J Mol Sci. 2021;22(11):5420.
  15. Wetering MVD, Francies HE, Francis JM, et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell. 2015;161(4):933–945.
  16. Sveen A, Bruun J, Eide PW, et al. Colorectal cancer consensus molecular subtypes translated to preclinical models uncover potentially targetable cancer cell dependencies. Clin Cancer Res. 2018;24(4):794–806.
  17. Zhang Y, Xu J, Yu Y, et al. Anticancer drug sensitivity assay with quantitative heterogeneity testing using single-cell raman spectroscope. Molecules. 2018;23(11):2903.
  18. Wang JK, Lin KC, Hu HJ, et al. In vitro anticancer drug sensitivity sensing through single-cell raman spectroscopy. Biosensors. 2021;11(8):286.
  19. Hammoud MK, Yosef HK, Lechtonen TL, et al. Raman micro-spectroscopy monitors acquired resistance to targeted cancer therapy at the cellular level. Scientific Reports. 2018;8(1):15278.
  20. Lu DY, Lu TR. Drug sensitivity testing, a unique drug selection strategy. Advances in Biomarker Sciences and Technology. 2020;14(3):59–66.
  21. Popova AA, Levkin PA. Precision medicine in oncology: In vitro drug sensitivity and resistance test (DSRT) for selection of personalized anticancer therapy. Adv Therapeutics. 2020;3(2):1900100.
  22. Lu DY, Lu TR. Drug sensitivity testing for cancer therapy, technique analysis and trend. Curr Rev Clin Exp Pharmacol. 2021; 3451250.
  23. Fares J, Fares MY, Khachfe HH, et al. Molecular principles of metastasis, a hallmark of cancer revisited. Signal Transduct Target Ther. 2020;5(1):28.
  24. Parker AL, Benguigui M, Fornetti J, et al. Current challenges in metastasis research and future innovation for clinical translation. Clin Exp Metastasis. 2022;39(2):263–277.
  25. Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011;147(2):275–292.
  26. Lu DY, Lu TR, Xu B, et al. Anti-metastatic drug development, work out towards new direction. Medicinal Chemistry. 2018;8(7):192–196.
  27. Steeg PS. Targeting metastasis. Nat Rev Cancer. 2015;16(4):201–218.
  28. Lambert, AW, Pattabiraman DR, Weinberg RA. Emerging biological principles of metastasis. Cell. 2017;168(4):670–691.
  29. Ali I. Nano drugs: novel agents for cancer chemotherapy. Current Cancer Drug Targets. 2011;1(2):131–134.
  30. Makhtar M, Bilal M, Rahdar A, et al. Nanomaterials for diagnosis and treatment of brain cancer: recent update. Chemosensors. 2020;8(4):117.
  31. Ali I, Saleem K, Uddin R, et al. Natural products: human friendly anti-cancer medications. Egypt Pharm J. 2010;9(2):133–179.
  32. Lu DY, Lu TR, Lu Y, et al. Discover natural chemical drugs in modern medicines. Metabolomics. 2016;6(3):181.
  33. Pattanayak S. Alternative to antibiotics from herbal origin—outline of a comprehensive research project. Current Pharmacogenomics Personalized Medicine. 2018;16(1):9–62.
  34. Hu B, Du Q, Shen KP, et al. Principles and scientific basis of traditional cancer treatments. J Bioanalysis and Biomedicine. 2012;S6:005.
  35. Lu DY, Lu TR. Drug discoveries from natural resources. J Prim Health Care Gen Practice. 2019;3(1):28.
  36. Lu DY, Lu TR, Putta S, et al. Anticancer drug discoveries from herbal medicine. EC Pharmacology Toxicology. 2019;7(9):990–994.
  37. Lu DY, Lu TR. Herbal medicine in new era. Hos Pal Med Int Jnl. 2019;3(4):125–130.
  38. Lu DY, Chen EH, Wu HY, et al. Anticancer drug combination, how far we can go through? Anticancer Agents Med Chem. 2017;17(1):21–28.
  39. Lu DY, Lu TR, Yarla NS, et al. Drug combination in clinical cancer treatment. Rev Recent Clin Trials. 2017;12(3):202–211.
  40. Zhu H, Yang W, He LJ, et al. Upregulating Noxa by ER stress, celastrol exerts synergistic anticancer activity in combination with ABT-737 in human hepatocellular carcinoma cells. PLoS One. 2012;7(12):52333.
  41. Lu DY, Lu TR, Xu B, et al. Perspectives of personalized cancer therapy. Adv Biotech Micro. 2017;4(3):555637.
  42. Lu DY. Personalized cancer chemotherapy, an effective way for enhancing outcomes in clinics. Woodhead Publishing. 2015.
  43. Lu DY, Lu TR, Che JY, et al. Individualized cancer therapy, future approaches. Current Pharmacogenomics Personalized Medicine. 2018;16(2):156–163.
  44. Franssen LC, Lorenzi T, Burgess AEF, et al. A mathematical framework for modeling the metastatic spread of cancer. Bulletin Mathematical Biology. 2019;81:1965–2011.
  45. Lu DY, Lu TR. Mathematics or physics-majored students on the biomedical fields, insiders or outsiders? Metabolomics. 2015;6(1):142.
  46. Lu DY, Wu HY, Lu TR, et al. Updating biomedical studies by recruiting more mathematics or physics-majored talents. Metabolomics. 2016;6(2):e148.
  47. Lu DY, Lu TR, Lu Y, et al. The acquisition of mathematical language in biomedical articles. J Cell Developmental Biol. 2017;1(1):8.
  48. Kapil M, Verma A, Sareen R, et al. Palliative care—a small step, big result, an effort to achieve. Hos Pal Med Int Jnl. 2019;3(5):149–150.
  49. Prityko DA, Burkov IV, Safonov VV, et al. Palliative care for children, problems and ways to solve them. EC Clinical & Experimental anatomy. 2019;2(9):23–29.
  50. Lu DY, Wu HY, Shen Y, et al. Medical treatments for incurable diseases, palliative therapy. Hos Pal Med Int Jnl. 2019;(5):175–176.
  51. Lu DY, Lu TR, Chen EH, et al. Anticancer drug development, system updating and global participation. Cur Drug Ther. 2017;12(1):37–45.
  52. Rahimzadeh V, Bartlett G. Policies and practices of data-intensive primary care in the precision-medicine era. Internal Medicine Rev. 2017;3(9):1–14.
  53. Lu DY, Lu TR, Chen EH, et al. Keep up the pace of drug development evolution and expenditure. Cancer Rep Rev. 2018;2(5):165.
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