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Research Article Volume 14 Issue 1
A systematic review of Toupet and Nissen technique for treatment of GERD
Fernando Freire Lisboa, Gabriel Diniz Câmara Dantas, Ângelo Felipe Lima de Araújo Alves, Luanny Vitoria da Silva Oliveria, Fernando Freire Lisboa Jr
Received: May 08, 2026 | Published: May 21, 2026
Citation: Lisboa FF, Dantas GDC, Alves AFLA, et al. A systematic review of Toupet and Nissen technique for treatment of GERD. MOJ Surg. 2026;14(1):26-33. DOI: DOI: 10.15406/mojs.2026.14.00309
Abstract
Background: Gastroesophageal reflux disease (GERD) is a highly prevalent condition that impacts patients’ quality of life. When medical therapy fails, surgical treatment, particularly Nissen (NF) and Toupet fundoplication (TF), is indicated. Aims: To compare the efficacy, complications, and outcomes of NF and TF in GERD treatment. Methods: A systematic review was conducted in PubMed, Cochrane, SciELO, and LILACS (2002–2025). Randomized controlled trials and cohort studies comparing NF and TF with ≥12 months follow-up were included. Primary outcomes: postoperative dysphagia, reflux control. Secondary outcomes: PPI use, quality of life (QoL), reoperations. Results: Nine studies (2,130 patients) were included. Both techniques showed similar efficacy in reflux control. NF resulted in higher lower esophageal sphincter pressure but increased early postoperative dysphagia. TF preserved esophageal motility better and had lower early dysphagia rates. Long-term PPI use, QoL, and patient satisfaction were comparable. Conclusions: NF and TF are effective for GERD. NF increases sphincter pressure but with more dysphagia; TF offers better motility preservation and fewer side effects. Surgical choice should be individualized based on esophageal motility and patient characteristics.
Keywords: gastroesophageal reflux disease; nissen fundoplication; toupet fundoplication
©2026 Lisboa, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.