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Research Article Volume 18 Issue 3
Symptoms of ankylosing spondylitis and quality of life and work productivity: a systematic review
Robson Emmanuel Silva Sampaio, Hiago Sousa Bastos, Juliana Fonseca Cavalcante, Laiany Caroline dos Santos Silva, Michelline Joana Tenório Albuquerque Madruga Mesquita, Almir José Guimaraes Gouveia, Otto Mauro dos Santos Rosa, Marcelly Amanda Lucena Ericeira, Adiláo Freitas Costa de Lima, Consuelo Penha Castro Marques
Received: May 10, 2026 | Published: May 22, 2026
Citation: Marques CPC. Symptoms of ankylosing spondylitis and quality of life and work productivity: a systematic review. MOJ Orthop Rheumatol. 2026;18(3):86-93. DOI: 10.15406/mojor.2026.18.00745
Abstract
Introduction: Ankylosing spondylitis (AS), a member of the spondyloarthritis group, is a chronic immune-mediated inflammatory arthritis that primarily affects the axial skeleton and sacroiliac joints. The symptoms of AS are generally characterized by chronic pain and back stiffness, which can limit activities of daily living. In its advanced stage, AS can lead to complete ankylosis of the spine, a condition characterized by a severe reduction in mobility. The affected individual then experiences pain and a significant decline in functional ability. Objective: To clarify how the symptoms of ankylosing spondylitis affect quality of life and work. Methodology: Integrative literature review of articles published between 2020 and 2024 in the following databases: SciELO, MEDLINE, and LILACS, based on the guiding question: “What are the symptoms of ankylosing spondylitis and how do they affect quality of life and productivity at work?”. Results and discussion: AS significantly impairs quality of life and productivity at work, with low back pain being the most frequent and disabling symptom. Extraskeletal manifestations, neuropathic pain, fatigue, kinesiophobia, deformities, sleep disorders, and depressive and anxiety symptoms have been associated with AS. Presenteeism and absenteeism at work generate economic costs, highlighting the social impact of the disease. Final considerations: AS profoundly impacts patients’ quality of life and productivity at work, mainly due to functional limitations. Addressing the illness requires a holistic approach, public health strategies, and multidisciplinary care.
Keywords: ankylosing spondylitis, symptoms; quality of life, productivity at work, autoimmune diseases
©2026 Marques, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.
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