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Research Article Volume 3 Issue 2
Synthesis, characterization, antibacterial and antioxidant studies of oxetoquinolines
Nandhakumar R, Muthukumar K, Velmurugan K, Derin TD, Rajesh P, Rajesh Kannan V
Department of Chemistry, Karunya Institute of Technology and Sciences, India
Department of microbiology, Bharathidasan University, India
Received: January 31, 2019 | Published: March 22, 2019
Citation: Muthukumar K, Velmurugan K, Derin TD, et al. Synthesis, characterization, antibacterial and antioxidant studies of oxetoquinolines. MOJ Biorg Org Chem. 2019;3(2):38-43. DOI: 10.15406/mojboc.2019.03.00096
Abstract
A series of 2H-oxeto[2,3-b]quinolines have been synthesized involving the simple steps of oxidation, reduction and cyclization of 2-chloro-3-formyl quinolines. All the synthesized compounds were evaluated for their antibacterial screening and anti oxidant studies. Most of the compounds showed moderate to good activity against almost all the tested pathogens. In particular, compound 1e showed good antibacterial and antioxidant activity.
Keywords: 2-chloro-3-formyl quinolines, cyclization, oxetoquinolines, antibacterial, antioxidant studies, antimicrobial, antituberculosis, antimalarial, antiinflammatory, anticancer, antihypertensive, anti-HIV, synthetic protocol, 4N hydrochloric acid, sodiumborohydride reduction
©2019 Muthukumar, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.