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Research Article Volume 3 Issue 2
Local anesthetic effect of some benzoyl amino acids and phthalyl amino acids using hot-plate technique and pin pricking technique
Ghada A Taqa, Isam K Al-Khayat, Amer A Taqa
Department of Dental Basic Sciences, University of Mosul, Iraq
Received: February 18, 2019 | Published: April 8, 2019
Citation: Taqa GA, Al-Khayat IK, Taqa AA. Local anesthetic effect of some benzoyl amino acids and phthalyl amino acids using hot-plate technique and pin pricking technique. MOJ Biorg Org Chem. 2019;3(2):55-59. DOI: 10.15406/mojboc.2019.03.00099
Abstract
Alkyl and phenyl side chain amino acid were reacted with benzoyl chloride and phthalyl anhydride to give benzoyl amino acids and phthalyl amino acids respectively.
Materials and methods: These compounds were tested for their local anesthetic effect as ointment using Hot-Plate technique in mice and as sodium salt solution using Pin-Pricking technique in rabbits.Results showed that the local anesthetic effect of the prepared ointment using a Hot-plate test on mice revealed that all benzoyl amino acids were significant anesthetic effect. For Phthalyl amino acids, a hot-plate test for the local anesthetic effect showed no significant effect for Phthalylanine and Phthylvaline and significant effect for Phthylalglycine, Phthalyl methionine and Phthalylphenyl alanine compared with Vaseline. All studied Phthalyl amino acids showed a lowered local anesthetic effect than lidocaine ointment. For Pin Pricking test all benzoyl and Phthalyl amino acid exhibit anesthesia but lower than lidocaine solution. Conclusion: Prepared of benzoyl amino acids and phthalyl amino acids have significant local anesthetic effects, benzoglycine ointment showed a significant effect compared with other a significant benzoyl valine, Benzoyl leucine and Benzoyl phenylalanine. All studied Phthalyl amino acids showed a lowered local anesthetic effect than lidocaine ointment. And significant effect for Phthalylglycine, Phthalylmethionine and Phthalyl phenyl alanine compared with Vaseline (negative control).
Keywords: bezoylamino acids, phthalyl amino acids, local anesthetic effect, hot-plate technique, pin-pricking technique
©2019 Taqa, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.