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Review Article Volume 18 Issue 1
Safety, efficacy and advantages of day-case minimally invasive parathyroidectomy for localised parathyroid adenomas: a systematic review and evidence synthesis
Prathibha Nanoo, Punsiri Sanjeev Silva, Merlin Babu
Received: January 22, 2026 | Published: February 6, 2026
Citation: Nanoo P, Silva PS, Babu M. Safety, efficacy and advantages of day-case minimally invasive parathyroidectomy for localised parathyroid adenomas: a systematic review and evidence synthesis. J Otolaryngol ENT Res. 2026;18(1):10‒12. DOI: 10.15406/joentr.2026.18.00578
Abstract
Background: Minimally invasive parathyroidectomy (MIP) has largely replaced traditional bilateral neck exploration for the treatment of primary hyperparathyroidism (PHPT), offering comparable cure rates with reduced postoperative morbidity. Advances in preoperative localisation and intraoperative adjuncts have made MIP a safe option for day-case surgery. Objective: To systematically review the evidence on the safety, efficacy and clinical advantages of day-case minimally invasive parathyroidectomy for patients with localised parathyroid adenomas. Methods: A systematic literature search was conducted in PubMed/MEDLINE, Embase, Scopus and the Cochrane Library for studies published up to 1 st December 2025. Studies reporting outcomes of focused parathyroidectomy performed as a day-case procedure following preoperative localisation of a solitary adenoma were included. Data on complications, readmissions, biochemical cure rates, patient satisfaction and healthcare utilisation were extracted and synthesised narratively. Results: Eighteen studies (predominantly retrospective cohort studies and prospective case series) were included. Same-day discharge following MIP was safe in appropriately selected patients. Complication and readmission rates were low and comparable to those reported with overnight admission. Day-case MIP was associated with reduced length of hospital stay, lower healthcare costs and high patient satisfaction, without compromising surgical success or biochemical cure rates. Conclusion: Day-case minimally invasive parathyroidectomy is a safe, effective and patient-centred approach for managing primary hyperparathyroidism in patients with localised disease. Wider adoption of ambulatory MIP pathways may optimise healthcare resource utilisation while maintaining excellent clinical outcomes.
Keywords: primary hyperparathyroidism, minimally invasive parathyroidectomy, day-case surgery, ambulatory surgery, intraoperative parathyroid hormone
©2026 Nanoo, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.