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Research Article Volume 8 Issue 2
Pulmonary tuberculosis among Sudanese individuals of White Nile state: Prevalence and role of the socio-demographic features and laboratory findings in the assessment of infection
Samah Sidahmed MS Elsafi, Bakri Mohammed Nour, Abakar Adam Dawoud, Izzedeen Haroun Omer, Babiker Saad Almugadam
Department of Medical Microbiology, Kosti Teaching Hospital, Sudan
Department of Medical Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan
Department of Parasitology, Blue Nile National Institute for Communicable Diseases, University of Gezira, Sudan
Department of Medicine, Faculty of Medicine, University of El Imam El Mahdi, Sudan
Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi, Sudan
Received: January 18, 2020 | Published: March 11, 2020
Citation: Elsafi SSMS, Nour BM, Dawoud AA, et al. Pulmonary tuberculosis among Sudanese individuals of White Nile state: Prevalence and role of the sociodemographic features and laboratory findings in the assessment of infection. J Microbiol Exp. 2020;8(2):52-63. DOI: 10.15406/jmen.2020.08.00285
Abstract
Background: Tuberculosis (TB) is a bacterial disease that can be spread through the air. It usually attacks the lungs, but it can also affect and damage the other parts of the body such as the brain, kidneys, or spine. Globally, the disease remains to be a major health problem in countries suffering from poverty and unsettlement like Sudan. Our study aimed to evacuate the prevalence of pulmonary TB and the value of the socio-demographic characteristic of patients and laboratory findings in the assessment of tuberculosis infection.
Methods: During the period from May 2017 to December2018, 1434 subjects were included. M.tuberculosis infection was examined using Ziehl-Neelsen (ZN) stain and GeneXpert test, and Human immunodeficiency virus infection was checked by the immuno-chromatographic test. Results: Out of 1434 participants, 795 (55.4%) were males and 639 (44.6%) were females as well as 670 (46.7%) were suffering from infection relapse. The percentage of HIV infection, MTB detection, and RF resistance among the study contributors was 1.4%, 16.5%, and 15.5%, respectively. Infection relapse was more in females than males. Among the medically suspected new participants (449), the overall reported prevalence for pulmonary TB was 15.8% based on the Gene Xpert test. Furthermore, the percentage of RF resistance was lower in females than males and participants age 1-20 years compared to 21-40, 41-60, and 61-80 age groups. There was a significant difference in the microscopy findings among disease history, bacillary levels and RF susceptibility patterns, P-values less than 0.05. Moreover, the odd of detection of a high bacillary level was significantly less likely in females than males. Whereas, it is higher in case of treatment failure and infection with RF resistant strain, P-values less than 0.05.
Conclusions: The findings of the current study were illustrated the current prevalence of pulmonary TB and shown the value of socio-demographic features and laboratory findings in the assessment of pulmonary tuberculosis infection.
Keywords: HIV, pulmonary tuberculosis, rifampicin, Xpert MTB/RIF, ZN stain
©2020 Elsafi, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.