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Mini Review Volume 6 Issue 1
In vitro Synergistic Effect of Colistin in Combination with Meropenem and Rifampin against Carbapenem-Resistant E. coli and K. pneumoniae
Nachimuthu Ramesh, Prasanth Manohar, Niharika Pandey, Thamaraiselvan Shanthini, Subramani Ramkumar
Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, India
Department of Microbiology, Hi-Tech Diagnostic Centre, India
Received: December 07, 2017 | Published: February 8, 2018
Citation: Manohar P, Pandey N, Shanthini T, Ramkumar S, Ramesh N (2018) In vitro Synergistic Effect of Colistin in Combination with Meropenem and Rifampin against Carbapenem-Resistant E. coli and K. pneumoniae. J Microbiol Exp 6(1): 00183. DOI: 10.15406/jmen.2018.06.00183
Abstract
Combination therapy is being investigated in order to improve the clinical success of colistin. We assessed the activity of colistin in combination with meropenem/rifampin against carbapenem-resistant isolates. Synergy occurred in vitroin all the tested isolates in which colistin minimal inhibitory concentration (MIC) values were at sub-MIC levels. There was no significant difference observed in our results between checkerboard and plate synergy method. Our findings indicated the utility of plate synergy method in order to predict the activity of specific antibiotic combinations. More importantly, these combinational drugs could be a good candidate for carbapenem-resistant bacterial infections.
Keywords: Combination therapy, Checkerboard, Plate synergy method, Synergism, Colistin, Rifampin, Meropenem, Antibiotic, Bacterial Infections, Carbapenem-Resistant, Pathogenic Bacteria, Drug, Monotherapy, Klebsiella pneumoniae, Escherichia coli, microtiter, E-strip
©2018 Manohar, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.