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Editorial Volume 9 Issue 4
Differences in levels of plasma, salivary, and nasal antibody to SARS-CoV-2 (Covid-19) after Covid-19 vaccination and during natural infection
Attapon Cheepsattayakorn,1,2 
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Ruangrong Cheepsattayakorn,3 Porntep Siriwanarangsun1
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1Faculty of Medicine, Western University, Thailand
210th Zonal Tuberculosis and Chest Disease Center, Thailand
3Department of Pathology, Faculty of Medicine, Chiang Mai University, Thailand
Correspondence: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, 143 Sridornchai Road Changklan Muang Chiang Mai 50100 Thailand
Received: December 19, 2022 | Published: December 23, 2022
Citation: Cheepsattayakorn A, Cheepsattayakorn R, Siriwanarangsun P. Differences in levels of plasma, salivary, and nasal antibody to SARS-CoV-2 (Covid-19) after Covid-19 vaccination and during natural infection. J Lung Pulm Respir Res. 2022;9(4):100. DOI: 10.15406/jlprr.2022.09.00288
Editorial
Cellular or antibody responses is measured in the most studies of immunity to SARS-CoV-2 (COVID-19).1 Nevertheless, if ever SARS-CoV-2 (COVID-19) present in the plasma, the infectious virus is rarely infects the nasal and conjunctival mucosal surfaces.1 In COVID-19-infected-unvaccinated and unvaccinated-COVID-19-uninfected individuals, the levels of nasal and salivary anti-spike antibody correlated significantly with plasma antibody.1,2 The reported mean correlations for titers in plasma and saliva for IgG and IgA were moderate (p = 0.55; 95 % CI : 0.38-9.73) and weak (p = 0.28; 95 % CI : 0.12-0.44), respectively.2 A previous systematic review demonstrated that previous-COVID-19-infected-vaccinated individuals demonstrated boosting anti-spike antibody levels in the nose or saliva less than in plasma.1
In conclusion, potent immune response induced by COVID-19 mucosal vaccines at the sites of SARS-CoV-2 (COVID-19) infection is urgently needed. Persistent mucosal antibody may not indicate persistent increase of SARS-CoV-2 plasma antibody levels.
Acknowledgments
None.
Conflicts of interest
There are no conflicting interests declared by the authors.
References
- Cohen JI, Dropulic L, Wang K, et al. Comparison of levels of nasal, salivary, and plasma antibody to SARS-CoV-2 during natural infection and after vaccination. Clin Infect Dis.2022.
- Guerra ENS, De Castro VT, Dos Santos JA, et al. Saliva is suitable for SARS-CoV-2 antibodies detection after vaccination: a rapid systematic review. Front Immunol. 2022.
©2022 Cheepsattayakorn, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.