Journal of eISSN: 2376-0060 JLPRR

Lung, Pulmonary & Respiratory Research
Volume 1 Issue 1 - 2014
Hematological Manifestations in Patients with Newly Diagnosed Pulmonary Tuberculosis
Attapon Cheepsattayakorn1* and Ruangrong Cheepsattayakorn2
1Department of Disease Control, 10th Zonal Tuberculosis and Chest Disease Center, Thailand
2Department of Pathology, Chiang Mai University, Thailand
Received: August 22, 2014 | Published: August 23, 2014
*Corresponding author: Attapon Cheepsattayakorn, Department of Disease Control, 143 Sridornchai Road Changklan Muang, Chiang Mai 50100, Thailand, Tel: 66-53-140767; Fax: 66-53-140773; Email: @
Citation: Cheepsattayakorn A, Cheepsattayakorn R (2014) Hematological Manifestations in Patients with Newly Diagnosed Pulmonary Tuberculosis. J Lung Pulm Respir Res 1(1): 00005.


Tuberculosis (TB), particularly TB is still a major public health problem of the world. Pulmonary eosinophilia [1,2], Hypereosinophilia [3], Reactivethrombocytosis [4-6], Thrombocytopenia [7], Disseminated intravascular coagulation [8], Deep venous thrombosis [9], Henoch-Schonlein purpura [10-12], Leukocytosis with neutrophilia [7,13], Lymphocytopenia [11,14], Monocytopenia, Lymphocytosis, Monocytosis [7], Severe leukopenia [7,15], Idiopathic thrombocytopenic purpura [16,17], Pancytopenia [7,13,18] Could be found in patients with newly diagnosed pulmonary TB.

Hereditary Glucose-6-Phosphate Dehydrogenase Deficiency and Pulmonary Tuberculosis

A study in Azerbaijan, a state of former Soviet Union demonstrated that the etiological role of this abnormality as a genetic marker for pulmonary TB was 14% in associated pulmonary tuberculosis and alcoholism, it grew to 18% [19]. Another study in this region also showed a high incidence of this hereditary disorder among patients with pulmonary TB [20].

Hematological Malignancies and Pulmonary Tuberculosis

Pulmonary military TB have been reported among patients with acute myeloid leukemia, chronic myeloid leukemia, acute lymphocytic leukemia, Hodgkin’s disease, T-cell lymphoma and myelodysplastic syndrome [21-23].

Sickle Cell Disease and Tuberculosis

Sickle cell disease was reported in patients with TB in France and Africa [24-26]. Many reports suggest that severe pulmonary TB in association with reduced tissue cellular reaction may cause blood dyscrasias. Anemia was present in 32% of cases. Leucopenia with neutropenia and lymphopenia was seen in 15% of patients with very severe clinical TB. Active tuberculosis was associated with significant reductions in absolute numbers of B lymphocytes, but there were no significant differences in total T8-cell counts [15]. There was reversal of T4//T8 ratio due to T4 lymphopenia. A study in Nigeria showed that 95% had normochromic picture while 5% demonstrated anisopoikilocytosis and polychromasia. The mean platelet counts did not change significantly from the initial value [27].


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