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Dental Health, Oral Disorders & Therapy

Case Series Volume 10 Issue 1

Laser therapy on dental emergencies of patients with hemophilia as an alternative for hemostasis and reducing the use of factor VIII concentrate

Laura Beatriz Isidro Olán,1 Marco Antonio Rueda Ventura,2 Carlos Alberto Balcazar Najera,1 Armando Najera Castro1

1Master degree in Public Health, Juárez Autonomous University of Tabasco, Mexico
2Master degree in Medical Education, Juárez Autonomous University of Tabasco, Mexico

Correspondence: Laura Beatriz Isidro Olan, Master degree in Public Health, Juárez Autonomous University of Tabasco, Tabasco, Mexico, Tel 9933601300

Received: January 25, 2019 | Published: February 20, 2019

Citation: Olán LBI, Ventura MAR, Rivera HHC. Laser therapy on dental emergencies of patients with hemophilia as an alternative for hemostasis and reducing the use of factor VIII concentrate. J Dent Health Oral Disord Ther. 2019;10(1):88-89. DOI: 10.15406/jdhodt.2019.10.00464

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Hemophilia is a hereditary disease, where the coagulation system is affected by the reduction of one of the coagulating factors, in this case factor VIII. In patients with hemophilia, oral bleeding is common, antihemophilic factor is not always available and it is extremely important to achieve hemostasis with other resources such as laser therapy. 

Laser (Light amplification by stimulated emission of radiation)

Laser classification depends on low and high intensity. Bioestimulatory, analgesic and antinflamatory action are achieved by low intensity machines such As, Ga (Gallium arsenide); As, Ga, Al (Gallium and aluminum arsenide); He, Ne (hHelium, neon). High intensity laser machines produce visible and physical effects in oral tissues and can be a substitute for cold scalpel or for conventional high rotatory instrument. Er:YAG (Erbium:Ytrium-Aluminum-Garnet) Laser has bactericidal effects against periodontal pathogenic bacteria and also eliminate bacterial endotoxins. Different tissue effects according to the temperature reached in a laser machine are showed in Table 1. In these cases series the temperature oscilated between 70-90 Celsius degrees to achieve hemostasis in different types of emergency oral bleeding.


Tissue effects


Transient hyperthermia


Desiccation and protein denaturation


Coagulation and tissue fusion

> 100°C


> 200°C


Table 1 Tissue effects according to the temparature reached


To optimize the use of factor VIII in emergencies and dental treatment through the use of Er:YAG laser therapy.

Material and methods

This case series included 6 patients with an age range between 4-11 years who had different types of emergency oral bleeding (extractions, lip laceration and pulp polyp removal) for which the Er: YAG laser emission was used in order to achieve hemostasis and optimize the use of factor VIII. In extraction cases (3), a single initial dose of 25 IU/kg / body weight was applied in two patients and the other received a dose of 50 IU/kg/body weight. In the cases of lip laceration and pulp polyp, factor was not used. In the case or dentoalveolar trauma a single initial dose of 25 IU/kg/body weight was applied (Figures 1-6).

Figure 1 Extraction case 1.

Figure 2 Upper lip lacerations (Case 2).

Figure 3 Pulp polyp removal (Case 3).

Figure 4 Extraction (Case 4).

Figure 5 Multiple extractions (Case 5).

Figure 6 Dentoalveolar traumas (Case 6).


In all the cases, after the first application of the Er: YAG laser, hemostasis was achieved and that allowed observation for a second application of Er: YAG if necessary. Only a second application was done in one case (Table 2).


Dental diagnosis

Required factor VIII

Factor viii owing to the management of the Er: yag laser


Temporary tooth extraction (73)

750 IU every 12hrs /1st day (2 dose) y 3rd dose 24 hrs after=2,250 IU

25 IU/kg (25 kg) single dose=750 IU


Laceration of upper lip

25 IU/Kg/12 hrs for 2 days=2600 IU

25 IU /kg=750 IU single dose


Pulp polyp removal

25 UI/Kg/12 hrs for first 24 hrs=1,250 IU

750 IU single dose


Temporary tooth extraction (53)

750 IU/8 hrs*24hrs=2,250 UI, e/12*48hrs=3000UI , Total dose= 5,250 IU

25 IU/kg=750 IU single dose


Multiple extractions ( 52,51,61,62)

50 UI /Kg /8hrs *1st day, e/12 hrs *2nd &3rd days, 25IU/Kg/24 4th & 5th day, same dose if necessary until recovery Total dose=10,000 IU

50 IU /kg (15)=750 IU 1st dose ; 750 IU 2nd dose/ 24 hrs after=1,500 IU


Dentoalveolar trauma

25 IU /kg (15Kg)=375 IU for 3 days every 12 hrs =2,250 U.I **3000 IU**

25 IU/kg (15 kg)=375 IU=*500 IU single dose*

Table 2 Reduction of Factor VIII owing to the management of the Er:YAG laser therapy


In all the cases the use of the factor was reduced between 60-80%, and this also reduces the possibility to develop inhibitors. The saved factor can be used for other medical emergencies of hemophilic patients. The new alternative therapies for oral management in hemophilia patients such laser therapies, reduces pain, inflammatory responses and also patient stress.


Tabasqueña de Hemofilia A.C and Hospital de Alta Especialidad del Niño: Dr Rodolfo Nieto Padrón..

Conflict of interest

The author declares that there is no conflicts of interest.

Creative Commons Attribution License

©2019 Olán, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.