Journal of
eISSN: 2373-4345
Submit manuscript...
Case Report Volume 7 Issue 2
Ameloblastic Carcinoma: Clinico-Pathological and Immunohistochemical Claudin Study
Gabriel Fernando Paredes-Ferrera, Constantino Ledesma-Montes, María Dolores Jiménez-Farfán, Carlos Contreras-Castellanos, José Espinoza-Fernández, Florentino Hernández-Flores, Alejandro Macario-Hernández, Claudio Viveros-Amador, Juan Carlos Hernández-Guerrero
Received: January 01, 1971 | Published: April 25, 2017
Citation: Paredes-Ferrera GF, Ledesma-Montes C, Jiménez-Farfán MD, Contreras-Castellanos C, Espinoza-Fernández J, et al. (2017) Ameloblastic Carcinoma: Clinico-Pathological and Immunohistochemical Claudin Study. J Dent Health Oral Disord Ther 7(2): 00234. DOI: 10.15406/jdhodt.2017.07.00234
Abstract
1.1. Background: Ameloblastic carcinoma (AC) is a rare and locally aggressive malignant odontogenic neoplasm found in the maxillomandibular area. Altered expression of claudins is associated to increased proliferation, loss of polarity and cell to cell adhesion, reorganization of the cytoskeleton and motility in cancer. Clinico-pathological characteristics and claudin immunoexpression was made in an AC derived from a unicystic ameloblastoma (UA).
1.2. Methods: We studied an AC in a 18-year-old woman, performing immunostaining with anti-PCNA and claudin-1, -3 and -9 antibodies.
1.3. Results: A malignant ill-differentiated neoplasm, composed by densely packed epithelial cells, and arranged in a solid growth pattern was found. Peripheral cells were ameloblastic, and central cells presented variable shapes with hyperchromatic, pleomorphic nuclei, prominent nucleoli and increased nucleus-cytoplasm ratio. Areas suggesting early neoplastic invasion were detected. The tumor was immunopositive to claudin-1 in cytoplasm and nucleus and negative to claudins -3 and -9.
1.4. Conclusion: AC derived from a UA showed a heterogenic claudins immunostaining. The altered claudin immunoexpression in the tumor and early invasion areas, coinciding with PCNA positive proliferative cells, suggest their important role in tumorigenesis and support the theory that claudins are highly tissue-specific and their functions may depend on the cell type and the tumor stage.
Keywords: Odontogenic, Tumors, Ameloblastic, Carcinoma, Ameloblastoma, Unicystic, Ameloblastoma, Claudins, Tight junction, Proteins, Claudins
©2017 Paredes-Ferrera, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.