Journal of
eISSN: 2373-4396
Submit manuscript...
Case Report Volume 18 Issue 2
High density lipoprotein and infection
K.K. Shalia, V. K. Shah
Received: May 22, 2025 | Published: June 18, 2025
Citation: Shalia KK, Shah VK. High density lipoprotein and infection. J Cardiol Curr Res. 2025;18(2):28-33. DOI: 10.15406/jccr.2025.18.00621
Abstract
Among the lipids only high density lipoprotein (HDL), carrying out Reverse Cholesterol Transport is anti- atherogenic and thus termed as “good cholesterol”. However, functions of its other components, such as apoliporpteins, enzymes providing protection against oxidative stress, inflammation, coagulation, endothelial dysfunction, apoptosis and modulating immune response as well as having a role in host defence to infection, makes it overall “good lipid”. Its composition can change and shift to another subclass in the presence of risk factors like a cardiovascular or foreign infection thus may not then be protective all the time. Thus, physicochemical composition and quality of HDL can be decisive for its harmful or useful effects. The strong inverse relationship between low HDL levels and infection suggest HDL to have a key role in infectious pathogenesis and therefore considered as good therapeutic target. In the present review, Its role in bacterial and viral pathogenesis is discussed.
Keywords: apolipoprotein, bacterial, viral, Covid 19, infection, serum lipid levels, host defence
©2025 Shalia, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.