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Review Article Volume 12 Issue 4
Congenital diaphragmatic hernia: current repair strategies and future directions in treatment
Russ, Kiersten, Tawil Bill
Received: June 27, 2025 | Published: July 18, 2025
Citation: Russ, Kiersten, Bill T. Congenital diaphragmatic hernia: current repair strategies and future directions in treatment. J Appl Biotechnol Bioeng 2025;12(3):144-150. DOI: 10.15406/jabb.2025.12.00396
Abstract
Congenital diaphragmatic hernia (CDH) is a serious and life-threatening birth defect caused by malformation of the diaphragm, allowing abdominal organs to herniate into the thoracic cavity and compress the lungs. While minor cases can be corrected surgically, large and complex defects require synthetic or biological patch repair. Synthetic materials like expanded polytetrafluoroethylene (ePTFE) offer high mechanical strength but suffer from poor tissue integration and increased infection risk. Biological scaffolds offer biocompatibility and potential for remodeling but often lack mechanical durability. This paper reviews the current landscape of CDH treatment, including patch materials in clinical use, market trends, and emerging innovations in biomaterials that seek to overcome existing limitations.
Keywords: congenital diaphragmatic hernia, patch repair, tissue engineering, biomaterials
©2025 Russ,, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.