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Review Article Volume 12 Issue 3
Acne vulgaris scars: a review of disease mechanisms, market trends, and emerging technologies
Sloan Iris, Tawil Bill
Received: June 17, 2025 | Published: July 4, 2025
Citation: Iris S, Bill T. Acne vulgaris scars: a review of disease mechanisms, market trends, and emerging technologies. J Appl Biotechnol Bioeng. 2025;12(3):121-129. DOI: 10.15406/jabb.2025.12.00394
Abstract
Acne vulgaris is a chronic inflammation of the pilosebaceous glands that affects approximately 85% of adolescents. After healing, acne scars may remain due to skin damage during the healing process of active acne. These scars can be categorized as atrophic or hypertrophic/keloidal. Atrophic scars can be further classified as ice-pick, boxcar, or rolling. According to Grand View Research, the global topical scar treatment market is expected to grow significantly from 2025 to 2030, with a Compound Annual Growth Rate (CAGR) of 11.9%. Current treatment options for acne scars include ablative and nonablative lasers, chemical peels, skin fillers, microneedling, thread lifting, dermabrasion, and platelet-rich plasma. Clinical trials are also exploring innovative technologies, such as combinations of polynucleotides with hyaluronic acid, topical insulin, and Alexandrite lasers. Additionally, preclinical research studies are exploring growth factor and exosome treatments. There remains an urgent need for acne scar treatments specifically tailored for patients with darker skin tones.
Keywords: acne scars, atrophic scars, laser treatment, collagen remodeling, combination therapy, tissue engineering
©2025 Iris, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.