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Case Report Volume 11 Issue 1
S100-negative secretory carcinoma of thyroid, mimicking papillary thyroid carcinoma: a diagnostic pitfall resolved by next generation sequencing
Ahsan Farooq, Nicole Fye, Sohira Malik
Received: March 10, 2026 | Published: April 2, 2026
Citation: Farooq A, Fye N, Malik S, et al. S100-negative secretory carcinoma of thyroid, mimicking papillary thyroid carcinoma: a diagnostic pitfall resolved by next generation sequencing. Int Clin Pathol J. 2026;11(1):1-3. DOI: 10.15406/icpjl.2026.11.00220
Abstract
Secretory thyroid carcinoma (STC) is an extremely rare disease and demonstrates the ETV6-NRK3 fusion gene. The majority of the cases have cribriform to solid architecture with eosinophilic cells and intraluminal secretion and immunohistochemistry staining with S100, GATA-3, mammoglobin and negative for PAX-8 and TTF-1. We present a challenging case of Secretory Carcinoma of the thyroid with PTC-like nuclear features and S100 negativity.
Keywords: head and neck, endocrine thyroid, secretory carcinoma
©2026 Farooq, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.